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- W2016076173 abstract "Electron microscope autoradiography of thyroid glands from rats previously injected with 125I labelled sodium iodide has been used to demonstrate the position of bound iodine up to 4 hr after administration. The techniques used give an autoradiographic resolution of about 0.25 μ. From 3 min to 4 hr, the extracellular colloid is increasingly labelled, grains being randomly distributed over most follicles, although a few follicles at 3, 5, 30 min and 4 hr had fewer grains over the central region. Except for a small number of cells in autoradiographs at 3 and 5 min the number of grains over thyroid cells was not different from background. It was concluded that the results favour hypotheses which consider iodine binding to occur initially in the extracellular colloid pool. Iodine binding may occur due to rapid diffusion of non-iodinated glycoprotein to all parts of each extracellular pool, or because exchange between radioactive and non-radioactive iodine occurs at the same time as the initial binding of iodine to newly formed thyroglobulin. No evidence has been obtained that any resorption of labelled colloid occurs during the first 4 hr after iodide administration." @default.
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- W2016076173 date "1965-04-01" @default.
- W2016076173 modified "2023-09-24" @default.
- W2016076173 title "An electron microscopic study of the site of iodine binding in the rat thyroid gland" @default.
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- W2016076173 doi "https://doi.org/10.1016/0014-4827(65)90426-x" @default.
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