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- W2016076204 abstract "In vivo interleukin (IL)-2, IL-4, IL-10, and interferon (IFN)-gamma production was measured at the mRNA transcript and protein levels in patients acutely infected with Plasmodium falciparum and during convalescence. Both IL-10 and IFN-gamma but not IL-2 were produced regardless of the patients' clinical severity. IL-4 production was variable. Circulating IFN-gamma and IL-10 were significantly higher in patients with severe disease (P < .01 and .001, respectively). In vitro stimulation of peripheral blood mononuclear cells (PBMC) by malarial antigens during acute infection showed that although there was no lymphoproliferation, the cells could produce IL-10 and IFN-gamma. Recombinant human IL-10 completely abolished in vitro tumor necrosis factor (TNF)-alpha production in response to malarial antigens, as well as the antigen-specific proliferative response of convalescent patients. However, anti-IL-10 was insufficient to restore proliferation of PBMC from acutely infected patients. These findings suggest that IL-10 may have an important negative feedback action on the production of inflammatory cytokines in acute falciparum malaria without contributing to the defect in antigen-specific proliferation." @default.
- W2016076204 created "2016-06-24" @default.
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- W2016076204 date "1995-09-01" @default.
- W2016076204 modified "2023-09-23" @default.
- W2016076204 title "Interleukin-10 Inhibits Tumor Necrosis Factor Production but Not Antigen-Specific Lymphoproliferation in Acute Plasmodium falciparum Malaria" @default.
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- W2016076204 doi "https://doi.org/10.1093/infdis/172.3.838" @default.
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