FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016076282> ?p ?o ?g. }

• W2016076282 endingPage "14174" @default.
• W2016076282 startingPage "14169" @default.
• W2016076282 abstract "Diisopropyl fluorophosphate (DFP) causes neurotoxicity related to an irreversible inhibition of acetylcholinesterase (AChE). Management of this intoxication includes: ( i ) pretreatment with reversible blockers of AChE, ( ii ) blockade of muscarinic receptors with atropine, and ( iii ) facilitation of GABA A receptor signal transduction by benzodiazepines. The major disadvantage associated with this treatment combination is that it must to be repeated frequently and, in some cases, protractedly. Also, the use of diazepam (DZP) and congeners includes unwanted side effects, including sedation, amnesia, cardiorespiratory depression, and anticonvulsive tolerance. To avoid these treatment complications but safely protect against DFP-induced seizures and other CNS toxicity, we adopted the strategy of administering mice with ( i ) small doses of huperzine A (HUP), a reversible and long-lasting (half-life ≈5 h) inhibitor of AChE, and ( ii ) imidazenil (IMI), a potent positive allosteric modulator of GABA action selective for α 5 -containing GABA A receptors. Coadministration of HUP (50 μg/kg s.c., 15 min before DFP) with IMI (2 mg/kg s.c., 30 min before DFP) prevents DFP-induced convulsions and the associated neuronal damage and mortality, allowing complete recovery within 18–24 h. In HUP-pretreated mice, the ED 50 of IMI to block DFP-induced mortality is ≈10 times lower than that of DZP and is devoid of sedation. Our data show that a combination of HUP with IMI is a prophylactic, potent, and safe therapeutic strategy to overcome DFP toxicity." @default.
• W2016076282 created "2016-06-24" @default.
• W2016076282 creator A5001147683 @default.
• W2016076282 creator A5026395120 @default.
• W2016076282 creator A5042503656 @default.
• W2016076282 creator A5048825104 @default.
• W2016076282 creator A5051515082 @default.
• W2016076282 creator A5053936847 @default.
• W2016076282 creator A5090826335 @default.
• W2016076282 date "2008-09-16" @default.
• W2016076282 modified "2023-09-23" @default.
• W2016076282 title "The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice" @default.
• W2016076282 cites W1971336985 @default.
• W2016076282 cites W1973177829 @default.
• W2016076282 cites W1978714737 @default.
• W2016076282 cites W1982076782 @default.
• W2016076282 cites W1985554234 @default.
• W2016076282 cites W1987980841 @default.
• W2016076282 cites W1988530810 @default.
• W2016076282 cites W1990584558 @default.
• W2016076282 cites W1991209555 @default.
• W2016076282 cites W1992294123 @default.
• W2016076282 cites W1994003799 @default.
• W2016076282 cites W2000945972 @default.
• W2016076282 cites W2010210144 @default.
• W2016076282 cites W2019049150 @default.
• W2016076282 cites W2025664076 @default.
• W2016076282 cites W2037742830 @default.
• W2016076282 cites W2041197821 @default.
• W2016076282 cites W2048489815 @default.
• W2016076282 cites W2048700405 @default.
• W2016076282 cites W2051841492 @default.
• W2016076282 cites W2058881895 @default.
• W2016076282 cites W2062923618 @default.
• W2016076282 cites W2065957780 @default.
• W2016076282 cites W2072551779 @default.
• W2016076282 cites W2083623577 @default.
• W2016076282 cites W2089700993 @default.
• W2016076282 cites W2103946141 @default.
• W2016076282 cites W2111730808 @default.
• W2016076282 cites W2121056064 @default.
• W2016076282 cites W2149928573 @default.
• W2016076282 cites W2164712597 @default.
• W2016076282 cites W2167071150 @default.
• W2016076282 cites W2169533599 @default.
• W2016076282 cites W2790490266 @default.
• W2016076282 doi "https://doi.org/10.1073/pnas.0807172105" @default.
• W2016076282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2544596" @default.
• W2016076282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18784370" @default.
• W2016076282 hasPublicationYear "2008" @default.
• W2016076282 type Work @default.
• W2016076282 sameAs 2016076282 @default.
• W2016076282 citedByCount "29" @default.
• W2016076282 countsByYear W20160762822012 @default.
• W2016076282 countsByYear W20160762822013 @default.
• W2016076282 countsByYear W20160762822014 @default.
• W2016076282 countsByYear W20160762822015 @default.
• W2016076282 countsByYear W20160762822016 @default.
• W2016076282 countsByYear W20160762822017 @default.
• W2016076282 countsByYear W20160762822019 @default.
• W2016076282 countsByYear W20160762822020 @default.
• W2016076282 countsByYear W20160762822022 @default.
• W2016076282 countsByYear W20160762822023 @default.
• W2016076282 crossrefType "journal-article" @default.
• W2016076282 hasAuthorship W2016076282A5001147683 @default.
• W2016076282 hasAuthorship W2016076282A5026395120 @default.
• W2016076282 hasAuthorship W2016076282A5042503656 @default.
• W2016076282 hasAuthorship W2016076282A5048825104 @default.
• W2016076282 hasAuthorship W2016076282A5051515082 @default.
• W2016076282 hasAuthorship W2016076282A5053936847 @default.
• W2016076282 hasAuthorship W2016076282A5090826335 @default.
• W2016076282 hasBestOaLocation W20160762821 @default.
• W2016076282 hasConcept C126322002 @default.
• W2016076282 hasConcept C170493617 @default.
• W2016076282 hasConcept C181199279 @default.
• W2016076282 hasConcept C185592680 @default.
• W2016076282 hasConcept C2776814716 @default.
• W2016076282 hasConcept C2776873056 @default.
• W2016076282 hasConcept C2778816929 @default.
• W2016076282 hasConcept C29730261 @default.
• W2016076282 hasConcept C31896038 @default.
• W2016076282 hasConcept C33789571 @default.
• W2016076282 hasConcept C42219234 @default.
• W2016076282 hasConcept C55493867 @default.
• W2016076282 hasConcept C71924100 @default.
• W2016076282 hasConcept C98274493 @default.
• W2016076282 hasConceptScore W2016076282C126322002 @default.
• W2016076282 hasConceptScore W2016076282C170493617 @default.
• W2016076282 hasConceptScore W2016076282C181199279 @default.
• W2016076282 hasConceptScore W2016076282C185592680 @default.
• W2016076282 hasConceptScore W2016076282C2776814716 @default.
• W2016076282 hasConceptScore W2016076282C2776873056 @default.
• W2016076282 hasConceptScore W2016076282C2778816929 @default.
• W2016076282 hasConceptScore W2016076282C29730261 @default.
• W2016076282 hasConceptScore W2016076282C31896038 @default.
• W2016076282 hasConceptScore W2016076282C33789571 @default.
• W2016076282 hasConceptScore W2016076282C42219234 @default.
• W2016076282 hasConceptScore W2016076282C55493867 @default.

• next