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• W2016076829 abstract "In Brief Purpose: To evaluate retinal function in a rabbit model after subconjunctival delivery of carboplatin in balanced saline solution (BSS) or fibrin sealant to determine possible retinal toxicity. Methods: One group of rabbits (n = 5) received a unilateral subconjunctival injection of 12.2 ± 1.0 mg/mL of carboplatin (Paraplatin) in BSS. Another group of rabbits (n = 5) received 25.1 ± 7.7 mg/mL of carboplatin in fibrin sealant (Hemaseel APR). Rabbits injected with fibrin sealant only (n = 2) and BSS only (n = 2) were used as control groups. Electroretinographic recordings consisted of a series of intensities presented under dark- and light-adapted conditions. Electroretinograms were recorded before the injection (baseline) and 2 days, 1, 2, and 3 weeks after the injection. After 3 weeks, all rabbit eyes were obtained for histopathologic examination. Results: Transient reductions in the dark-adapted b-wave amplitudes were noted 2 days after treatment for eyes injected with carboplatin compared with the vehicle-only treatment groups. Other treatment groups and postinjection time points showed no significant changes from baseline. Retinal structure and thickness were normal 3 weeks after treatment for all treatment groups. Conclusion: Subconjunctival delivery of carboplatin in fibrin sealant or BSS does not have a toxic effect on retinal function or structure in a non-tumor-bearing rabbit model at the doses used in this study at 3 weeks’ follow-up. Subconjunctival injections of carboplatin in BSS or fibrin sealant were formed in a rabbit model. ERG recordings taken for 3 weeks after treatment indicate a transient decrease in retinal function after injection that returns to baseline values by 1 week postinjection." @default.
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• W2016076829 date "2004-10-01" @default.
• W2016076829 modified "2023-10-18" @default.
• W2016076829 title "RETINAL FUNCTION AFTER SUBCONJUNCTIVAL INJECTION OF CARBOPLATIN IN FIBRIN SEALANT" @default.
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• W2016076829 doi "https://doi.org/10.1097/00006982-200410000-00015" @default.
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