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- W2016077331 endingPage "39" @default.
- W2016077331 startingPage "15" @default.
- W2016077331 abstract "The phosphatidylinositol phosphate (PIP) kinases are a unique family of enzymes that generate an assortment of lipid messengers, including the pivotal second messenger phosphatidylinositol 4,5-bisphosphate (PI4,5P2). While members of the PIP kinase family function by catalyzing a similar phosphorylation reaction, the specificity loop of each PIP kinase subfamily determines substrate preference and partially influences distinct subcellular targeting. Specific protein-protein interactions that are unique to particular isoforms or splice variants play a key role in targeting PIP kinases to appropriate subcellular compartments to facilitate the localized generation of PI4,5P2 proximal to effectors, a mechanism key for the function of PI4,5P2 as a second messenger. This review documents the discovery of the PIP kinases and their signaling products, and summarizes our current understanding of the mechanisms underlying the localized generation of PI4,5P2 by PIP kinases for the regulation of cellular events including actin cytoskeleton dynamics, vesicular trafficking, cell migration, and an assortment of nuclear events." @default.
- W2016077331 created "2016-06-24" @default.
- W2016077331 creator A5022226283 @default.
- W2016077331 creator A5033937372 @default.
- W2016077331 creator A5046540673 @default.
- W2016077331 creator A5055281869 @default.
- W2016077331 creator A5059181659 @default.
- W2016077331 creator A5070902642 @default.
- W2016077331 creator A5083885393 @default.
- W2016077331 date "2007-01-01" @default.
- W2016077331 modified "2023-10-03" @default.
- W2016077331 title "A Conspicuous Connection: Structure Defines Function for the Phosphatidylinositol-Phosphate Kinase Family" @default.
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