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- W2016079632 abstract "Design, synthesis, and evaluation of 14-methoxy-84-methylsulfonyl-22,33,42,53,62,73-hexa(Gla-Leu-Lys-Leu-NH2)-p-octiphenyl (1) and 14,84-bismethoxy-22,33,42,53,62,73-hexa(Gla-Leu-Lys-Leu-NH2)-p-octiphenyl (2) are described (Gla = -OCH2CO-). Nanomolar concentrations of push-pull rod 1 are found to suffice to selectively form ion channels in polarized spherical bilayer membranes composed of egg yolk phosphatidylcholine. Exponential dependence of the ion-channel activity on membrane polarization reveals a gating charge of 0.85/channel. Independence of the activity of push-push rod 2 on membrane potential demonstrates that cell membrane recognition originates from the axial dipole in push-pull rod 1. Nonlinear concentration dependence of activity at -180 mV indicates parallel self-assembly of push-pull rod 1 into a tetrameric barrel-stave supramolecule." @default.
- W2016079632 created "2016-06-24" @default.
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- W2016079632 date "2002-01-26" @default.
- W2016079632 modified "2023-09-25" @default.
- W2016079632 title "Recognition of Polarized Lipid Bilayers byp-Oligophenyl Ion Channels: From Push−Pull Rods to Push−Pull Barrels" @default.
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- W2016079632 doi "https://doi.org/10.1021/ja017497c" @default.
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