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• W2016083532 abstract "The effect of delta 8-THC on experimental autoimmune encephalomyelitis (EAE) was examined. delta 8-THC is an analogue of delta 9-THC, the psychoactive component of marijuana. It is more stable and less psychotropic than delta 9-THC and like the latter it binds to the brain cannabinoid receptor. Two strains of rats were inoculated for EAE, and delta 8-THC (40 mg/kg) was administered for up to 21 days. delta 8-THC significantly reduced the incidence and severity of neurological deficit in both rat strains. The beneficial influence of delta 8-THC only occurred on oral administration and not with parenteral injection. Serum corticosterone levels were twofold elevated in rats with EAE chronically treated with delta 8-THC. These results suggest that suppression of EAE by cannabinoids may be related to their effect on corticosterone secretion." @default.
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• W2016083532 date "1994-11-01" @default.
• W2016083532 modified "2023-09-24" @default.
• W2016083532 title "Suppression of experimetal autoimmune encephalomyelitis by cannabinoids" @default.
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• W2016083532 doi "https://doi.org/10.1016/0162-3109(94)90056-6" @default.
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