FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016084361> ?p ?o ?g. }

• W2016084361 abstract "Low serum cholesterol levels are related to an increased risk of depression and its serious consequences. However, the effect of central cholesterol on depressive disorder and its potential regulatory mechanism is poorly understood. Therefore, brain cholesterol in patients with depression may not only decrease the risk for developing this disease but also increase the beneficial effects of treatment for depression.In current study, rats were exposed to chronic mild stress (CMS) for consecutive 28 days, and the depressive-like behavior was tested by sucrose preference test, immobility in the forced swim test, locomotor activity in the open field test, decreased bodyweight and food intake. Additionally, the total cholesterol levels in the medial prefrontal cortex (mPFC) and the hippocampus of rats were measured by gas chromatograph mass spectrometer. Finally, 5-HT1A receptor antagonist WAY100635 was used to determine the potential role of serotonin system in the interaction between central cholesterol and depression.CMS significantly reduced total cholesterol levels in the mPFC but not in the hippocampus and resulted in depressive-like behavior. Chronic supplementation of cholesterol by food reversed the depressive-like behavior induced by CMS. Furthermore, pre-injection of 5-HT1A receptor antagonist WAY100635 into the mPFC blocked the treatment effects of cholesterol on the reversal of behavioral response.This finding suggested that cholesterol in the mPFC may have an impact on the sensitivity of the 5-HT1A receptor in the development and treatment of depression. The treatment benefits of cholesterol could be through modulation of the brain 5-HT1A receptor." @default.
• W2016084361 created "2016-06-24" @default.
• W2016084361 creator A5009961945 @default.
• W2016084361 creator A5018907559 @default.
• W2016084361 creator A5060942745 @default.
• W2016084361 creator A5087559347 @default.
• W2016084361 creator A5088888083 @default.
• W2016084361 date "2015-03-24" @default.
• W2016084361 modified "2023-10-14" @default.
• W2016084361 title "Reduced cholesterol is associated with the depressive-like behavior in rats through modulation of the brain 5-HT1A receptor" @default.
• W2016084361 cites W1489343241 @default.
• W2016084361 cites W1581595716 @default.
• W2016084361 cites W18758181 @default.
• W2016084361 cites W1957115984 @default.
• W2016084361 cites W1971469548 @default.
• W2016084361 cites W1973386992 @default.
• W2016084361 cites W1975478041 @default.
• W2016084361 cites W1977283296 @default.
• W2016084361 cites W1979025169 @default.
• W2016084361 cites W1980788065 @default.
• W2016084361 cites W1983839288 @default.
• W2016084361 cites W1987748345 @default.
• W2016084361 cites W1990394752 @default.
• W2016084361 cites W2003303561 @default.
• W2016084361 cites W2004613749 @default.
• W2016084361 cites W2006745592 @default.
• W2016084361 cites W2012392799 @default.
• W2016084361 cites W2015449772 @default.
• W2016084361 cites W2028375480 @default.
• W2016084361 cites W2030571181 @default.
• W2016084361 cites W2033348549 @default.
• W2016084361 cites W2037409999 @default.
• W2016084361 cites W2042248547 @default.
• W2016084361 cites W2042284982 @default.
• W2016084361 cites W2048292311 @default.
• W2016084361 cites W2050836998 @default.
• W2016084361 cites W2051978768 @default.
• W2016084361 cites W2054695075 @default.
• W2016084361 cites W2055805394 @default.
• W2016084361 cites W2060676930 @default.
• W2016084361 cites W2064539835 @default.
• W2016084361 cites W2065196794 @default.
• W2016084361 cites W2068198508 @default.
• W2016084361 cites W2073131735 @default.
• W2016084361 cites W2075770088 @default.
• W2016084361 cites W2076710424 @default.
• W2016084361 cites W2077794554 @default.
• W2016084361 cites W2080667948 @default.
• W2016084361 cites W2081363371 @default.
• W2016084361 cites W2081534285 @default.
• W2016084361 cites W2081560912 @default.
• W2016084361 cites W2084313555 @default.
• W2016084361 cites W2099681709 @default.
• W2016084361 cites W2107366236 @default.
• W2016084361 cites W2108980934 @default.
• W2016084361 cites W2120111449 @default.
• W2016084361 cites W2120376279 @default.
• W2016084361 cites W2123684145 @default.
• W2016084361 cites W2133371501 @default.
• W2016084361 cites W2152059360 @default.
• W2016084361 cites W2152895520 @default.
• W2016084361 cites W2153210395 @default.
• W2016084361 cites W2157305460 @default.
• W2016084361 cites W2160104852 @default.
• W2016084361 cites W2162406652 @default.
• W2016084361 cites W2323052420 @default.
• W2016084361 cites W2357420288 @default.
• W2016084361 cites W28614200 @default.
• W2016084361 cites W72255980 @default.
• W2016084361 doi "https://doi.org/10.1186/s12944-015-0020-7" @default.
• W2016084361 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4377184" @default.
• W2016084361 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25889773" @default.
• W2016084361 hasPublicationYear "2015" @default.
• W2016084361 type Work @default.
• W2016084361 sameAs 2016084361 @default.
• W2016084361 citedByCount "33" @default.
• W2016084361 countsByYear W20160843612015 @default.
• W2016084361 countsByYear W20160843612016 @default.
• W2016084361 countsByYear W20160843612017 @default.
• W2016084361 countsByYear W20160843612018 @default.
• W2016084361 countsByYear W20160843612019 @default.
• W2016084361 countsByYear W20160843612020 @default.
• W2016084361 countsByYear W20160843612021 @default.
• W2016084361 countsByYear W20160843612022 @default.
• W2016084361 countsByYear W20160843612023 @default.
• W2016084361 crossrefType "journal-article" @default.
• W2016084361 hasAuthorship W2016084361A5009961945 @default.
• W2016084361 hasAuthorship W2016084361A5018907559 @default.
• W2016084361 hasAuthorship W2016084361A5060942745 @default.
• W2016084361 hasAuthorship W2016084361A5087559347 @default.
• W2016084361 hasAuthorship W2016084361A5088888083 @default.
• W2016084361 hasBestOaLocation W20160843611 @default.
• W2016084361 hasConcept C126322002 @default.
• W2016084361 hasConcept C134018914 @default.
• W2016084361 hasConcept C136569192 @default.
• W2016084361 hasConcept C15744967 @default.
• W2016084361 hasConcept C169760540 @default.
• W2016084361 hasConcept C169900460 @default.
• W2016084361 hasConcept C170493617 @default.
• W2016084361 hasConcept C2775864247 @default.

• next