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• W2016085798 abstract "Glutaminyl-tRNA synthetase and asparaginyl-tRNA synthetase evolved from glutamyl-tRNA synthetase and aspartyl-tRNA synthetase, respectively, after the split in the last universal communal ancestor (LUCA). Glutaminyl-tRNAGln and asparaginyl-tRNAAsn were likely formed in LUCA by amidation of the mischarged species, glutamyl-tRNAGln and aspartyl-tRNAAsn, by tRNA-dependent amidotransferases, as is still the case in most bacteria and all known archaea. The amidotransferase GatCAB is found in both domains of life, while the heterodimeric amidotransferase GatDE is found only in Archaea. The GatB and GatE subunits belong to a unique protein family that includes Pet112 that is encoded in the nuclear genomes of numerous eukaryotes. GatE was thought to have evolved from GatB after the emergence of the modern lines of decent. Our phylogenetic analysis though places the split between GatE and GatB, prior to the phylogenetic divide between Bacteria and Archaea, and Pet112 to be of mitochondrial origin. In addition, GatD appears to have emerged prior to the bacterial–archaeal phylogenetic divide. Thus, while GatDE is an archaeal signature protein, it likely was present in LUCA together with GatCAB. Archaea retained both amidotransferases, while Bacteria emerged with only GatCAB. The presence of GatDE has favored a unique archaeal tRNAGln that may be preventing the acquisition of glutaminyl-tRNA synthetase in Archaea. Archaeal GatCAB, on the other hand, has not favored a distinct tRNAAsn, suggesting that tRNAAsn recognition is not a major barrier to the retention of asparaginyl-tRNA synthetase in many Archaea." @default.
• W2016085798 created "2016-06-24" @default.
• W2016085798 creator A5063450287 @default.
• W2016085798 creator A5064100926 @default.
• W2016085798 date "2008-03-01" @default.
• W2016085798 modified "2023-10-17" @default.
• W2016085798 title "On the Evolution of the tRNA-Dependent Amidotransferases, GatCAB and GatDE" @default.
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• W2016085798 doi "https://doi.org/10.1016/j.jmb.2008.01.016" @default.
• W2016085798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2366055" @default.
• W2016085798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18279892" @default.
• W2016085798 hasPublicationYear "2008" @default.
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