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- W2016086327 abstract "The present study shows the evaluation of Leu-Enkephalin (Leu-Enk) encapsulation on core-shell isobutylcyanoacrylate/thiolated chitosan (IBCA/ChitoTBA) nanoparticles as a tool of combined system of polymers and colloidal particles for oral administration of poor absorption drugs. Leu-Enk encapsulation using anionic emulsion polymerization technique was carried out previous depolymerization of MW 400,000 gmol1 commercial chitosan, followed by thiolation of this depolymerized chitosan with Traut's reagent (2-iminothiolane), and final characterization. Later, direct quantification of the encapsulated Leu-Enk into the nanoparticles was carried out evaluating two methodologies for nanoparticles rupture solubilization with: NaOH 1 N and DMSO. Physico-chemical characterization of the obtained nanoparticles showed diameters in the nano-range between 28 and 46 nm, and yields of encapsulation of Leu-Enk between 25 and 46%, and recovery yields over 96% for co-polymer nanoparticles solubilization method with DMSO." @default.
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- W2016086327 date "2008-12-01" @default.
- W2016086327 modified "2023-10-01" @default.
- W2016086327 title "ENCAPSULATION OF LEU-ENKEPHALIN IN CORE-SHELL ISOBUTYLCYANOACRYLATE - THIOLATED CHITOSAN NANOPARTICLES FOR ORAL ADMINISTRATION" @default.
- W2016086327 doi "https://doi.org/10.4067/s0717-97072008000400008" @default.
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