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- W2016086863 abstract "Background The mucosal surface is the major route for HIV-1 transmission, yet a safe and effective AIDS vaccine through direct mucosal immunization remains elusive. Methods Here, we report a novel vaccination regimen consisting of a mucosal prime with replication-competent vaccinia Tiantan rMVTTSIVgpe and an intramuscular boost with non-replicating rAd5SIVgpe expressing SIV Gag, Pol and Env. Twenty Chinese rhesus macaques were used to evaluate its safety, immunogenicity and protective potential. Results Compared with three control groups, the rMVTTSIVgperAd5SIVgpe regimen elicited robust cellular immune responses with enhanced magnitude, sustainability and polyfunctionality, and higher titers of neutralizing antibodies against SIVmac1A11. Moreover, one rMVTTSIVgperAd5SIVgpe vaccinated animal was fully protected, while the rest demonstrated 1.74-log and 1.2-log reductions in peak and set-point viral loads upon intrarectal challenge with a high dose (5x105 TCID50/animal) of a pathogenic and neutralization-resistant SIVmac239. Importantly, the rMVTTSIVgpe-rAd5SIVgpe vaccinated animals remained healthy up to 850 days post-challenge, while the majority (~75%) of controls progressed to simian AIDS. The protective effect was found to correlate with SIV-specific CD8+ T cell ELIspot responses against Gag and Pol, but not Env. Conclusion Our findings indicate that vaccine strategy engaging the mucosal surface from the beginning of vaccination may provide protective immunity against HIV-1 infection in humans." @default.
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- W2016086863 date "2012-09-01" @default.
- W2016086863 modified "2023-10-01" @default.
- W2016086863 title "Immune control of an SIV challenge by a heterolgous and direct mucosal vaccination regimen in rhesus monkeys" @default.
- W2016086863 doi "https://doi.org/10.1186/1742-4690-9-s2-o3" @default.
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