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- W2016086945 abstract "Following a brief introduction to properties of the red blood cell (RBC), this review will provide information pertaining to the role of the RBC as both a deliverer of nitric oxide (NO), and a stimulator of NO release via RBC- generated ATP. In addition, an evaluation of the potential downstream effects of RBC-derived ATP, via its ability to stimulate NO in other cell types, will be provided. Collectively, it is now apparent that the RBC is a determinant in functions other than oxygen delivery alone. The average human red blood cell (RBC) has a volume of approximately 87 femtoliters, is about 6-7 μm in diameter, and spends, on average 110-120 days in the human body before being metabolized by such organs as the spleen. RBCs also represent about 40-45% of the total blood volume in an adult human (5 L); thus, the average adult has about 2 L of RBCs. The RBC also has many unique features in comparison to other cell types in vivo in that it lacks a nucleus and has no mitochondria. However, the RBC is not completely void of cell machinery; indeed, it has a very active cell bilayer, possesses a glucose transporter (GLUT1), has many of the same ion pumps as other cells, and is even thought to participate in the overall control of blood flow." @default.
- W2016086945 created "2016-06-24" @default.
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- W2016086945 date "2011-10-21" @default.
- W2016086945 modified "2023-09-27" @default.
- W2016086945 title "The Red Blood Cell and Nitric Oxide: Derived, Stimulated, or Both?" @default.
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- W2016086945 doi "https://doi.org/10.2174/1875042701103010008" @default.
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