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- W2016087069 abstract "Functional properties of the in vitro frog gastric mucosa were studied during fixation with glutaraldehyde (G4) or OsO4. The acid secretory rate dropped quickly and was completely absolished within 5–15 min. When fixative was added to either the serosal or mucosal surface of the mucosa the potential difference decreased rapidly within the first minute and frequently became temporarily inverted. The electrical resistance changes almost always included an initial drop. With GA added to either side and with OsO4 added to the serosal side the resistance then rose to values above the controls, again returning to very low values after intervals usually between 15 min and 2 h. With OsO4 added to the mucosal side the resistance decreased rapidly to low levels and did not recover. The selective permeability of the nutrient membrane of K+ over Na- was decreased within 5 to 10 min, but was not abolished until about 35 min after the addition of the fixatives, at which time the mucosal resistance was still high. It is concluded that the ion-conducting pathways in the plasma membranes are greatly changed by the fixatives, which should be taken into consideration when interpreting electron micro-graphs." @default.
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- W2016087069 date "1973-05-01" @default.
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- W2016087069 title "Influence of Fixation on Physiological Properties of Frog Gastric Mucosa" @default.
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- W2016087069 doi "https://doi.org/10.1111/j.1748-1716.1973.tb05438.x" @default.
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