FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016087474> ?p ?o ?g. }

• W2016087474 endingPage "166" @default.
• W2016087474 startingPage "160" @default.
• W2016087474 abstract "Objective: To evaluate the potential for clinically relevant drug interactions between ritonavir-boosted elvitegravir (EVG/r) and the nucleoside reverse transcriptase inhibitors (NRTIs) zidovudine (ZDV), didanosine (ddI), stavudine (d4T), or abacavir (ABC) upon coadministration. Methods: In 3 studies, healthy subjects were administered a single dose of ddI, d4T, or ABC, or multiple doses of ZDV, followed by multiple doses of EVG/r alone and together with an NRTI; pharmacokinetics (PK) of EVG and NRTIs were evaluated after individual administration and coadministration. Lack of PK alteration bounds (90% confidence intervals [CI]) for the NRTIs were based on the lack of PK-based dose adjustments per prescribing information. Results: Twenty-four of 28, 32/32, and 24/26 subjects completed the ZDV-EVG/r, ddI/d4T-EVG/r, and ABC-EVG/r studies, respectively. All study drugs were well tolerated and no serious adverse events were noted. The PK of ZDV, its glucuronide (G-ZDV), d4T, ABC, and EVG were within the lack of PK alteration 90% CI bounds upon coadministration. Exposures of ddI were modestly (∼15%) lower, but these changes are unlikely to be clinically meaningful. Conclusions: There are no clinically relevant drug interactions between EVG/r and the NRTIs zidovudine, didanosine, stavudine, or abacavir. These agents can be coadministered without dose adjustment." @default.
• W2016087474 created "2016-06-24" @default.
• W2016087474 creator A5000666965 @default.
• W2016087474 creator A5001083964 @default.
• W2016087474 creator A5037662740 @default.
• W2016087474 creator A5060657680 @default.
• W2016087474 creator A5074748590 @default.
• W2016087474 date "2007-10-01" @default.
• W2016087474 modified "2023-10-03" @default.
• W2016087474 title "Pharmacokinetics of Coadministered Ritonavir-Boosted Elvitegravir and Zidovudine, Didanosine, Stavudine, or Abacavir" @default.
• W2016087474 cites W1575280218 @default.
• W2016087474 cites W2007831756 @default.
• W2016087474 cites W2008137278 @default.
• W2016087474 cites W2045369251 @default.
• W2016087474 cites W2061212708 @default.
• W2016087474 cites W2072027413 @default.
• W2016087474 cites W2085468466 @default.
• W2016087474 cites W2126553984 @default.
• W2016087474 cites W2144984387 @default.
• W2016087474 cites W2169279535 @default.
• W2016087474 doi "https://doi.org/10.1097/qai.0b013e318151fd9a" @default.
• W2016087474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17693892" @default.
• W2016087474 hasPublicationYear "2007" @default.
• W2016087474 type Work @default.
• W2016087474 sameAs 2016087474 @default.
• W2016087474 citedByCount "30" @default.
• W2016087474 countsByYear W20160874742012 @default.
• W2016087474 countsByYear W20160874742013 @default.
• W2016087474 countsByYear W20160874742014 @default.
• W2016087474 countsByYear W20160874742015 @default.
• W2016087474 countsByYear W20160874742019 @default.
• W2016087474 countsByYear W20160874742021 @default.
• W2016087474 crossrefType "journal-article" @default.
• W2016087474 hasAuthorship W2016087474A5000666965 @default.
• W2016087474 hasAuthorship W2016087474A5001083964 @default.
• W2016087474 hasAuthorship W2016087474A5037662740 @default.
• W2016087474 hasAuthorship W2016087474A5060657680 @default.
• W2016087474 hasAuthorship W2016087474A5074748590 @default.
• W2016087474 hasBestOaLocation W20160874741 @default.
• W2016087474 hasConcept C112705442 @default.
• W2016087474 hasConcept C142462285 @default.
• W2016087474 hasConcept C159047783 @default.
• W2016087474 hasConcept C2522874641 @default.
• W2016087474 hasConcept C2777068322 @default.
• W2016087474 hasConcept C2777351918 @default.
• W2016087474 hasConcept C2777447569 @default.
• W2016087474 hasConcept C2777869810 @default.
• W2016087474 hasConcept C2779298103 @default.
• W2016087474 hasConcept C2779465607 @default.
• W2016087474 hasConcept C2779889181 @default.
• W2016087474 hasConcept C2780216070 @default.
• W2016087474 hasConcept C2780524789 @default.
• W2016087474 hasConcept C2780593183 @default.
• W2016087474 hasConcept C2780727368 @default.
• W2016087474 hasConcept C2993143319 @default.
• W2016087474 hasConcept C3013748606 @default.
• W2016087474 hasConcept C71924100 @default.
• W2016087474 hasConcept C97320921 @default.
• W2016087474 hasConcept C98274493 @default.
• W2016087474 hasConceptScore W2016087474C112705442 @default.
• W2016087474 hasConceptScore W2016087474C142462285 @default.
• W2016087474 hasConceptScore W2016087474C159047783 @default.
• W2016087474 hasConceptScore W2016087474C2522874641 @default.
• W2016087474 hasConceptScore W2016087474C2777068322 @default.
• W2016087474 hasConceptScore W2016087474C2777351918 @default.
• W2016087474 hasConceptScore W2016087474C2777447569 @default.
• W2016087474 hasConceptScore W2016087474C2777869810 @default.
• W2016087474 hasConceptScore W2016087474C2779298103 @default.
• W2016087474 hasConceptScore W2016087474C2779465607 @default.
• W2016087474 hasConceptScore W2016087474C2779889181 @default.
• W2016087474 hasConceptScore W2016087474C2780216070 @default.
• W2016087474 hasConceptScore W2016087474C2780524789 @default.
• W2016087474 hasConceptScore W2016087474C2780593183 @default.
• W2016087474 hasConceptScore W2016087474C2780727368 @default.
• W2016087474 hasConceptScore W2016087474C2993143319 @default.
• W2016087474 hasConceptScore W2016087474C3013748606 @default.
• W2016087474 hasConceptScore W2016087474C71924100 @default.
• W2016087474 hasConceptScore W2016087474C97320921 @default.
• W2016087474 hasConceptScore W2016087474C98274493 @default.
• W2016087474 hasIssue "2" @default.
• W2016087474 hasLocation W20160874741 @default.
• W2016087474 hasLocation W20160874742 @default.
• W2016087474 hasOpenAccess W2016087474 @default.
• W2016087474 hasPrimaryLocation W20160874741 @default.
• W2016087474 hasRelatedWork W2016087474 @default.
• W2016087474 hasRelatedWork W2083580679 @default.
• W2016087474 hasRelatedWork W2137568520 @default.
• W2016087474 hasRelatedWork W2162114586 @default.
• W2016087474 hasRelatedWork W2320051647 @default.
• W2016087474 hasRelatedWork W2397894039 @default.
• W2016087474 hasRelatedWork W2433924464 @default.
• W2016087474 hasRelatedWork W4236122306 @default.
• W2016087474 hasRelatedWork W4247194717 @default.
• W2016087474 hasRelatedWork W4299397867 @default.
• W2016087474 hasVolume "46" @default.
• W2016087474 isParatext "false" @default.
• W2016087474 isRetracted "false" @default.
• W2016087474 magId "2016087474" @default.

• next