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• W2016087560 startingPage "1533" @default.
• W2016087560 abstract "Supernatant protein factor (SPF) promotes the epoxidation of squalene catalyzed by microsomes. Several studies suggest its in vivo role in the cholesterol biosynthetic pathway by a yet unknown mechanism. SPF belongs to a family of lipid binding proteins called CRAL_TRIO, which include yeast phosphatidylinositol transfer protein Sec14 and tocopherol transfer protein TTP. The crystal structure of human SPF at a resolution of 1.9 A reveals a two domain topology. The N-terminal 275 residues form a Sec14-like domain, while the C-terminal 115 residues consist of an eight-stranded jelly-roll barrel similar to that found in many viral protein structures. The ligand binding cavity has a peculiar horseshoe-like shape. Contrary to the Sec14 crystal structure, the lipid-exchange loop is in a closed conformation, suggesting a mechanism for lipid exchange." @default.
• W2016087560 created "2016-06-24" @default.
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• W2016087560 date "2002-11-01" @default.
• W2016087560 modified "2023-09-27" @default.
• W2016087560 title "Crystal Structure of the Human Supernatant Protein Factor" @default.
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• W2016087560 doi "https://doi.org/10.1016/s0969-2126(02)00884-5" @default.
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