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• W2016089105 abstract "Abstract Based on previous chimpanzee studies of brain and behavior development and mother- infant interactions, a nonuniform distribution of diseases over age during infacy was predicted and found in a population of 98 human infants who experienced stress during the first years of their lives. The data were extracted from the case histories of these children when they were referred to the admissions and advisory panel of a special school at the age of 3–7 years. This finding was replicated in a longitudinal study of 20 healthy, normal infants. Parsimonious explanations of these results are discussed and found wanting. A more complex explanation is proposed: Infant development is characterized by abrupt, major reorganizations in the nervous system at quite specific ages. Through these reorganizations, a hierarchy of negative feedback control systems is built up. One type of control system after the other is emerging maturationally. During each reorganization, the organism is in a labile state. Consequently, very little additional stress is needed to throw the organism off balance. When this occurs, disease is more likely to occur. This explanation is in line with recent findings in the new discipline of psychoneuroimmunology. A review of human literature is presented in support of the Control Systems Theory of development underlying this explanation and the nation of vulnerable periods." @default.
• W2016089105 created "2016-06-24" @default.
• W2016089105 creator A5079528336 @default.
• W2016089105 date "1989-07-01" @default.
• W2016089105 modified "2023-09-26" @default.
• W2016089105 title "Vulnerable periods during infancy: Hierarchically reorganized systems control, stress, and disease" @default.
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• W2016089105 doi "https://doi.org/10.1016/0162-3095(89)90042-3" @default.
• W2016089105 hasPublicationYear "1989" @default.
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