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- W2016089217 abstract "Lactic acid bacteria (LAB) represent an attractive delivery vehicle for oral allergy vaccine because of their safety as a food microorganism as well as their potent adjuvant activity triggering anti-allergic immune response. Here, we report the generation of recombinant LAB expressing a major Japanese cedar pollen allergen Cry j 1 (Cry j 1-LAB), and their prophylactic effect in vivo. To facilitate heterologous expression, the codon usage in the Cry j 1 gene was optimized for the host LAB strain Lactobacillus plantarum by the recursive PCR-based exhaustive site-directed mutagenesis. Use of the codon-optimized Cry j 1 cDNA and a lactate dehydrogenase gene fusion system led to a successful production of recombinant Cry j 1 in L. plantarum NCL21. We also found that oral vaccination with the Cry j 1-LAB suppressed allergen-specific IgE response and nasal symptoms in a murine model of cedar pollinosis." @default.
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- W2016089217 date "2012-04-01" @default.
- W2016089217 modified "2023-09-27" @default.
- W2016089217 title "Prophylactic effect of Lactobacillus oral vaccine expressing a Japanese cedar pollen allergen" @default.
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- W2016089217 doi "https://doi.org/10.1016/j.jbiosc.2011.11.025" @default.
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