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- W2016089661 abstract "Rats pretreated with methergoline, cyproheptadine, cinanserin, methysergide or chlorimipramine were partially protected against the reduction in food intake elicited by a subsequent injection of 6 mg/kg of fenfluramine. With the exception of methergoline, none of these compounds attenuated the anorexigenic action of 3 or 1.5 mg/kg of fenfluramine. Prior treatment with α-methyl-p-tyrosine diminished the anorexic activity of 6 mg/kg of amphetamine, but this compound was ineffective against 3 or 1.5 mg/kg. The anorexigenic action of amphetamine, 6 or 3 mg/kg, was reduced by prior administration of haloperidol, whereas 1.5 mg/kg of amphetamine was not affected. All of the substances used for pretreatment exhibited selectivity, i.e. in no instance did an antagonist of fenfluramine also reduce the effect of amphetamine and vice versa. Animals pretreated with the indoleamine antagonists, chlorimipramine, α-methyl-p-tyrosine and haloperidol, were also tested with p-chloromethamphetamine. The results indicated that p-chloromethamphetamine cannot be classified as either primarily fenfluramine-like or amphetamine-like in its mode of action. It was concluded that 5-hydroxytryptamine is involved in the anorexigenic effect of high doses of fenfluramine, that catecholamines (principally dopamine) are important in the action of high (and perhaps intermediate) dose levels of amphetamine, and that the anorexia which follows low doses of fenfluramine and amphetamine occurs via mechanisms not involving 5-hydroxytryptamine, norepinephrine or dopamine." @default.
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- W2016089661 title "Role of monoamines in the anorexigenic actions of fenfluramine, amphetamine and p-chloromethamphetamine" @default.
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- W2016089661 doi "https://doi.org/10.1016/0014-2999(74)90006-5" @default.
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