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• W2016091731 abstract "A female toddler was referred to our hospital with the problem of hypertensive encephalopathy manifesting with convulsions, right hemiparesis and blindness. She had been well until the age of 17 months when she developed fever and symptoms of an upper respiratory tract infection. Her past medical history was significant only for having been a small for gestational age baby. She weighed 2 kg at birth after a term, uncomplicated pregnancy. She had achieved her milestones normally up to the age of 12 months. Thereafter her mother noticed that her neurological development was faltering—she was not talking or playing, she was disinterested in her environment and she was unusually irritable. She has no family history of hypertension, heart or kidney disease. She has one healthy sibling. On physical examination she appeared chronically ill. She was severely stunted (length 72.5 cm, Z score<−3 SD) and wasted (weight for length Z score<−3 SD). Her level of consciousness was depressed. All her pulses were present and normal and there was no radio-femoral delay. Her blood pressure was 148/92 mm Hg and was elevated in all four limbs. She had puffy eyes, but no pedal or sacral oedema. She was clinically anaemic and mildly dehydrated. She did not have any lymphadenopathy. There were no cafe au lait spots, no malar rash and no evidence of vasculitis. The left precordium was bulging. The apex was heaving in the fifth intercostal space, displaced laterally. The second heart sound was loud. There was no murmur over the heart, the subclavian or carotid vessels, over the inter-scapular area or abdominal aorta. There was weakness of the left arm and leg, and all tendon reflexes were markedly brisk. She had complete loss of vision, but her other cranial nerves were intact. Fundoscopy revealed retinal haemorrhages, but no papilloedema. Laboratory investigations revealed the following information: she had a hypokalaemic metabolic alkalosis; potassium was 2.8 mmol/l and bicarbonate was 30 mmol/l. The serum sodium, chloride, urea and creatinine levels were normal. The full blood count showed a hypochromic microcytic anaemia, with haemoglobin of 9.4 g/dl [normal 11.1–14.7 g/dl, mean corpuscular volume of 65.9 fl (normal 70–86 fl) and mean corpuscular haematocrit of 20.8 pg (normal 23–31 pg)]. The differential white cell count was normal. Further investigations showed a suppressed plasma immuno-reactive renin of <1.8 mIU/l (normal 5.4–28.8 mIU/l) and aldosterone level of <31 pmol/l (normal 28–666 pmol/l). The urine potassium was 21.7 mmol/l, urine sodium was <10 mmol/l and urine chloride was 20 mmol/l. The urine protein creatinine ratio was 0.23 g/mmol (normal <0.02 g/mmol). Steroid chromatography excluded endocrine causes of hypertension associated with hypokalaemic metabolic alkalosis. The kidney sonography showed normal-sized kidneys for her length of 72.5 cm (right 6.1×3.1 cm, left 5.8×3 cm), with decreased cortico-medullary differentiation. Renal The answers to these questions can be found at http://dx.doi.org/10.1007/ s00467-013-2446-3" @default.
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• W2016091731 date "2013-03-09" @default.
• W2016091731 modified "2023-09-27" @default.
• W2016091731 title "A rare cause of systemic hypertension in an African child: Questions" @default.
• W2016091731 doi "https://doi.org/10.1007/s00467-013-2445-4" @default.
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