FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016092074> ?p ?o ?g. }

• W2016092074 endingPage "22" @default.
• W2016092074 startingPage "15" @default.
• W2016092074 abstract "CYP2D6 gene encoding CYP2D6 enzyme belonging to the cytochrome P450 system has aroused long attention being a candidate gene for Alzheimer's disease (AD), but the results remain inconsistent and underpowered.To investigate the contradictory results, the effect of single CYP2D6 polymorphism- CYP2D6*4, together with CYP2D6 phenotypes on the risk of AD, was evaluated using a meta-analysis.Electronic database search of PubMed, Embase and Cochrane Library was conducted up to Apr 17, 2014. Odds ratio (OR) along with the 95% confidence interval (CI) was calculated. Subgroup analysis was performed to examine the impact of CYP2D6 variants on different ethnic. Meta-regression was performed to explore possible source of heterogeneity.A total of 11 studies involving 643AD cases and 1375 controls were included for CYP2D6*4 polymorphism, and 4 studies consisted of 411AD cases and 603 controls were included for CYP2D6 phenotypes. With respect to CYP2D6*4 polymorphism, significantly increased risk of AD was found in allelic contrast model of A vs. G (OR=1.29, 95%CI=1.03-1.62, P=0.026), co-dominant genetic model AA vs. GG (OR=1.91, 95%CI=1.04-3.51, P=0.038); and recessive genetic model AA vs. AG+GG (OR=1.88, 95%CI=1.03-3.46, P=0.041) in the overall populations. Similar results were also indicated in subgroup analysis in Caucasians. As for CYP2D6 phenotypes, no significant association with AD was revealed.Our data support that the CYP2D6*4 polymorphism but not CYP2D6 phenotypes might be associated with increased AD risk, particularly in Caucasian populations." @default.
• W2016092074 created "2016-06-24" @default.
• W2016092074 creator A5000306626 @default.
• W2016092074 creator A5004366207 @default.
• W2016092074 creator A5028593104 @default.
• W2016092074 creator A5029401819 @default.
• W2016092074 creator A5048507557 @default.
• W2016092074 creator A5052645254 @default.
• W2016092074 creator A5056328923 @default.
• W2016092074 creator A5064461058 @default.
• W2016092074 creator A5068675597 @default.
• W2016092074 creator A5077945540 @default.
• W2016092074 creator A5086899185 @default.
• W2016092074 date "2014-08-01" @default.
• W2016092074 modified "2023-09-25" @default.
• W2016092074 title "Quantitative assessment of CYP2D6 polymorphisms and risk of Alzheimer's disease: A meta-analysis" @default.
• W2016092074 cites W1522010415 @default.
• W2016092074 cites W1598300615 @default.
• W2016092074 cites W1966451439 @default.
• W2016092074 cites W1970314092 @default.
• W2016092074 cites W1970458151 @default.
• W2016092074 cites W1978323444 @default.
• W2016092074 cites W1979423827 @default.
• W2016092074 cites W1984737558 @default.
• W2016092074 cites W1984832259 @default.
• W2016092074 cites W1985334472 @default.
• W2016092074 cites W1991176470 @default.
• W2016092074 cites W1999316948 @default.
• W2016092074 cites W2001091274 @default.
• W2016092074 cites W2002123847 @default.
• W2016092074 cites W2010724535 @default.
• W2016092074 cites W2014886338 @default.
• W2016092074 cites W2020606858 @default.
• W2016092074 cites W2029205666 @default.
• W2016092074 cites W2037113639 @default.
• W2016092074 cites W2039651233 @default.
• W2016092074 cites W2039727503 @default.
• W2016092074 cites W2049578801 @default.
• W2016092074 cites W2054384828 @default.
• W2016092074 cites W2054773707 @default.
• W2016092074 cites W2060007515 @default.
• W2016092074 cites W2063933280 @default.
• W2016092074 cites W2066789280 @default.
• W2016092074 cites W2070245731 @default.
• W2016092074 cites W2073363005 @default.
• W2016092074 cites W2073668490 @default.
• W2016092074 cites W2082212339 @default.
• W2016092074 cites W2090364061 @default.
• W2016092074 cites W2090641365 @default.
• W2016092074 cites W2101692886 @default.
• W2016092074 cites W2104058573 @default.
• W2016092074 cites W2122992446 @default.
• W2016092074 cites W2135230337 @default.
• W2016092074 cites W2150138960 @default.
• W2016092074 cites W2155555055 @default.
• W2016092074 cites W2158891312 @default.
• W2016092074 cites W2168922978 @default.
• W2016092074 cites W4245386160 @default.
• W2016092074 doi "https://doi.org/10.1016/j.jns.2014.05.033" @default.
• W2016092074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24909950" @default.
• W2016092074 hasPublicationYear "2014" @default.
• W2016092074 type Work @default.
• W2016092074 sameAs 2016092074 @default.
• W2016092074 citedByCount "14" @default.
• W2016092074 countsByYear W20160920742015 @default.
• W2016092074 countsByYear W20160920742016 @default.
• W2016092074 countsByYear W20160920742017 @default.
• W2016092074 countsByYear W20160920742018 @default.
• W2016092074 countsByYear W20160920742019 @default.
• W2016092074 countsByYear W20160920742020 @default.
• W2016092074 countsByYear W20160920742021 @default.
• W2016092074 countsByYear W20160920742022 @default.
• W2016092074 crossrefType "journal-article" @default.
• W2016092074 hasAuthorship W2016092074A5000306626 @default.
• W2016092074 hasAuthorship W2016092074A5004366207 @default.
• W2016092074 hasAuthorship W2016092074A5028593104 @default.
• W2016092074 hasAuthorship W2016092074A5029401819 @default.
• W2016092074 hasAuthorship W2016092074A5048507557 @default.
• W2016092074 hasAuthorship W2016092074A5052645254 @default.
• W2016092074 hasAuthorship W2016092074A5056328923 @default.
• W2016092074 hasAuthorship W2016092074A5064461058 @default.
• W2016092074 hasAuthorship W2016092074A5068675597 @default.
• W2016092074 hasAuthorship W2016092074A5077945540 @default.
• W2016092074 hasAuthorship W2016092074A5086899185 @default.
• W2016092074 hasConcept C104317684 @default.
• W2016092074 hasConcept C126322002 @default.
• W2016092074 hasConcept C127716648 @default.
• W2016092074 hasConcept C135763542 @default.
• W2016092074 hasConcept C143998085 @default.
• W2016092074 hasConcept C149737253 @default.
• W2016092074 hasConcept C156957248 @default.
• W2016092074 hasConcept C180754005 @default.
• W2016092074 hasConcept C187960798 @default.
• W2016092074 hasConcept C33664856 @default.
• W2016092074 hasConcept C44249647 @default.
• W2016092074 hasConcept C54355233 @default.
• W2016092074 hasConcept C71924100 @default.
• W2016092074 hasConcept C86803240 @default.

• next