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• W2016092414 abstract "Mouse BC 3 H1 myoblasts were stably transfected with the adenovirus 5 E1A gene. One clonal line, BC 3 E7, was found to differ in some important respects from those previously reported for E1A-transformed myoblasts. In contrast to BC 3 H1 cells which differentiate when confluent in medium containing 0.5% fetal calf serum (FCS), BC 3 E7 cells failed to elongate and align, to express acetylcholine receptor and creatine kinase, and to down-regulate expression of β- and γ-actins and tropomyosin isoform (TM) 1. However, increased synthesis of TMs 2, 3, and 4, and myosin light chain 1 associated with differentiation in BC 3 H1 still occurred in BC 3 E7 cells, and most surprisingly, α-actin was produced at a significant level in both proliferating and confluent BC 3 E7 cells. Interestingly, myogenin was expressed in confluent BC 3 E7 cells in 0.5% FCS, but not in 20%. The level of E1A expression in BC 3 E7 cells was found to be very low by analysis of mRNA, by immunoprecipitation of E1A protein, and by the ability of BC 3 E7 cells to complement the E1A-deficient adenovirus mutant dl312. These results suggest that different levels of E1A may be needed to repress different promoters and that E1A does not block myogenic differentiation by repressing myogenin expression, but represses each muscle gene independently.Key words: actin, adenovirus 5 E1A, BC 3 H1 myoblasts, myogenin." @default.
• W2016092414 created "2016-06-24" @default.
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• W2016092414 date "1992-10-01" @default.
• W2016092414 modified "2023-09-26" @default.
• W2016092414 title "Disruption of the coordinate expression of muscle genes in a transfected BC3H1 myoblast cell line producing a low level of the adenovirus E1A transforming protein" @default.
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• W2016092414 doi "https://doi.org/10.1139/o92-173" @default.
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