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• W2016092527 abstract "1. The effects of pharmacologically elevated metabolism on ventilation, gaseous exchange and blood gases were studied in spontaneously breathing unanaesthetized decerebrate chickens using 2,4-dinitrophenol (DNP) injected intravenously in successive single doses of 2.5–5.0 mg/kg. These responses were compared with the cardiorespiratory adjustments to elevated metabolism evoked by shivering in conscious birds. 2. Oxygen consumption increased with cumulative amounts of DNP, reaching 275 ± 30% of control values at the maximum tolerated dose of 10–15 mg/kg. 3. Increases in ventilation matched the changes in oxygen consumption via increases in both breathing frequency and tidal volume. Arterial blood gases and pH remained unchanged. 4. Exposure to cold (Ta = 2 ± 2°C) caused oxygen consumption to increase to 185 ± 21% of control values. Respiratory and cardiovascular adjustments were similar to those evoked by DNP and were comparable to those produced by low intensity treadmill exercise (cf. Gleeson and Brackenbury, 1984)." @default.
• W2016092527 created "2016-06-24" @default.
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• W2016092527 date "1986-01-01" @default.
• W2016092527 modified "2023-09-24" @default.
• W2016092527 title "Respiratory adjustments of the unanaesthetized chicken, Gallus domesticus, to elevated metabolism elicited by 2,4-dinitrophenol or cold exposure" @default.
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• W2016092527 doi "https://doi.org/10.1016/0300-9629(86)90575-x" @default.
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