FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016093153> ?p ?o ?g. }

• W2016093153 endingPage "913" @default.
• W2016093153 startingPage "905" @default.
• W2016093153 abstract "SCL/Tal-1 is a helix-loop-helix (HLH) transcription factor required for blood cell development, whose abnormal expression is responsible for induction of T-cell acute lymphoblastic leukemia. We show here that SCL/Tal-1 is a key target of caspases in developing erythroblasts. SCL/Tal-1 degradation occurred rapidly after caspase activation and preceded the cleavage of the major erythroid transcription factor GATA-1. Expression of a caspase-resistant SCL/Tal-1 in erythroid progenitors was able to prevent amplification of caspase activation, GATA-1 degradation and impaired erythropoiesis induced by growth factor deprivation or death receptor triggering. The potent proerythropoietic activity of uncleavable SCL/Tal-1 was clearly evident in the absence of erythropoietin, a condition that did not allow survival of normal erythroid cells or expansion of erythroblasts expressing caspase-resistant GATA-1. In the absence of erythropoietin, cells expressing caspase-resistant SCL/Tal-1 maintain high levels of Bcl-X(L), which inhibits amplification of the caspase cascade and mediates protection from apoptosis. Thus, SCL/TAL-1 is a survival factor for erythroid cells, whereas caspase-mediated cleavage of SCL/Tal-1 results in amplification of caspase activation, GATA-1 degradation and impaired erythropoiesis." @default.
• W2016093153 created "2016-06-24" @default.
• W2016093153 creator A5008684425 @default.
• W2016093153 creator A5010700645 @default.
• W2016093153 creator A5017459750 @default.
• W2016093153 creator A5039618744 @default.
• W2016093153 creator A5042097944 @default.
• W2016093153 creator A5042442375 @default.
• W2016093153 creator A5055619996 @default.
• W2016093153 creator A5057975103 @default.
• W2016093153 creator A5077708146 @default.
• W2016093153 creator A5079412406 @default.
• W2016093153 creator A5080731572 @default.
• W2016093153 date "2003-07-17" @default.
• W2016093153 modified "2023-10-13" @default.
• W2016093153 title "Control of erythroid cell production via caspase-mediated cleavage of transcription factor SCL/Tal-1" @default.
• W2016093153 cites W103874031 @default.
• W2016093153 cites W122007457 @default.
• W2016093153 cites W1547637047 @default.
• W2016093153 cites W1554372630 @default.
• W2016093153 cites W1555869617 @default.
• W2016093153 cites W1575638464 @default.
• W2016093153 cites W1725765893 @default.
• W2016093153 cites W1912623443 @default.
• W2016093153 cites W1964538721 @default.
• W2016093153 cites W1966722028 @default.
• W2016093153 cites W1986340562 @default.
• W2016093153 cites W1988278983 @default.
• W2016093153 cites W2000894919 @default.
• W2016093153 cites W2023920753 @default.
• W2016093153 cites W2026688799 @default.
• W2016093153 cites W2051740914 @default.
• W2016093153 cites W2052329237 @default.
• W2016093153 cites W2061656021 @default.
• W2016093153 cites W2063176993 @default.
• W2016093153 cites W2063636969 @default.
• W2016093153 cites W2072453311 @default.
• W2016093153 cites W2082670705 @default.
• W2016093153 cites W2088692721 @default.
• W2016093153 cites W2091830776 @default.
• W2016093153 cites W2095075940 @default.
• W2016093153 cites W2109719547 @default.
• W2016093153 cites W2119483052 @default.
• W2016093153 cites W2124862621 @default.
• W2016093153 cites W2131727825 @default.
• W2016093153 cites W2147951044 @default.
• W2016093153 cites W2155884728 @default.
• W2016093153 cites W2155997583 @default.
• W2016093153 cites W2161995649 @default.
• W2016093153 cites W2169505995 @default.
• W2016093153 cites W2188189445 @default.
• W2016093153 cites W2202631807 @default.
• W2016093153 cites W2278285517 @default.
• W2016093153 cites W2414372705 @default.
• W2016093153 cites W2414627607 @default.
• W2016093153 cites W266334352 @default.
• W2016093153 cites W3719606 @default.
• W2016093153 cites W4230154929 @default.
• W2016093153 cites W4244668085 @default.
• W2016093153 cites W4255609769 @default.
• W2016093153 cites W5434598 @default.
• W2016093153 cites W91824008 @default.
• W2016093153 doi "https://doi.org/10.1038/sj.cdd.4401255" @default.
• W2016093153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12867998" @default.
• W2016093153 hasPublicationYear "2003" @default.
• W2016093153 type Work @default.
• W2016093153 sameAs 2016093153 @default.
• W2016093153 citedByCount "45" @default.
• W2016093153 countsByYear W20160931532012 @default.
• W2016093153 countsByYear W20160931532013 @default.
• W2016093153 countsByYear W20160931532014 @default.
• W2016093153 countsByYear W20160931532015 @default.
• W2016093153 countsByYear W20160931532017 @default.
• W2016093153 countsByYear W20160931532018 @default.
• W2016093153 countsByYear W20160931532019 @default.
• W2016093153 countsByYear W20160931532020 @default.
• W2016093153 crossrefType "journal-article" @default.
• W2016093153 hasAuthorship W2016093153A5008684425 @default.
• W2016093153 hasAuthorship W2016093153A5010700645 @default.
• W2016093153 hasAuthorship W2016093153A5017459750 @default.
• W2016093153 hasAuthorship W2016093153A5039618744 @default.
• W2016093153 hasAuthorship W2016093153A5042097944 @default.
• W2016093153 hasAuthorship W2016093153A5042442375 @default.
• W2016093153 hasAuthorship W2016093153A5055619996 @default.
• W2016093153 hasAuthorship W2016093153A5057975103 @default.
• W2016093153 hasAuthorship W2016093153A5077708146 @default.
• W2016093153 hasAuthorship W2016093153A5079412406 @default.
• W2016093153 hasAuthorship W2016093153A5080731572 @default.
• W2016093153 hasBestOaLocation W20160931531 @default.
• W2016093153 hasConcept C104317684 @default.
• W2016093153 hasConcept C109159458 @default.
• W2016093153 hasConcept C12519072 @default.
• W2016093153 hasConcept C126322002 @default.
• W2016093153 hasConcept C151730666 @default.
• W2016093153 hasConcept C153911025 @default.
• W2016093153 hasConcept C175156509 @default.
• W2016093153 hasConcept C190283241 @default.
• W2016093153 hasConcept C192196715 @default.

• next