FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016095843> ?p ?o ?g. }

• W2016095843 endingPage "e41049" @default.
• W2016095843 startingPage "e41049" @default.
• W2016095843 abstract "Uterine leiomyosarcoma is an aggressive tumor typically found at advanced stages due to difficulties with early diagnosis. Because uterine leiomyosarcoma is resistant to conventional radiation and chemotherapy, the development of more potent medical therapeutics is anticipated. Using quantitative real-time RT-PCR and immunostaining, we found the expression of brain-derived neurotrophic factor (BDNF) and neurotropin-4/5, together with their receptor, tyrosine kinase B (TrkB), in different uterine sarcoma cell lines and primary tumor samples from uterine leiomyosarcoma patients. We noted that levels of BDNF were more abundant than those of neurotropin-4/5. Moreover, the expression of TrkB and its ligands was elevated in a multidrug-resistant cell line and samples obtained from patients with leiomyosarcoma. In cultured uterine sarcoma cells, inhibition of endogenous TrkB signaling by treatment with either the soluble TrkB ectodomain or the Trk receptor inhibitor, K252a, suppressed cell proliferation and increased apoptosis based on cell viability and proliferation, in situ terminal deoxynucleotidyl transferase-mediated 2′-deoxyuridine 5′-triphosphate nick end-labeling and caspase-3/7 assays, whereas an inactive plasma membrane nonpermeable K252b was ineffective. Correspondingly, treatment with exogenous BDNF increased cell proliferation. In in vivo studies in athymic nude mice bearing multidrug-resistant uterine sarcoma cell tumors, we demonstrate suppression of tumor growth by treatment with K252a, but not K252b, as reflected by decreased cell proliferation and increased levels of apoptosis and caspase-3/7 activities without obvious side effects. Our findings indicated that endogenous signaling of the TrkB pathway contributed to uterine sarcoma cell growth, and inhibition of TrkB signaling in these tumors could provide a novel medical therapy for patients with uterine sarcomas." @default.
• W2016095843 created "2016-06-24" @default.
• W2016095843 creator A5014932121 @default.
• W2016095843 creator A5032344243 @default.
• W2016095843 creator A5048430036 @default.
• W2016095843 creator A5068095097 @default.
• W2016095843 creator A5080550942 @default.
• W2016095843 creator A5090160787 @default.
• W2016095843 date "2012-07-23" @default.
• W2016095843 modified "2023-09-27" @default.
• W2016095843 title "Inhibition of Uterine Sarcoma Cell Growth through Suppression of Endogenous Tyrosine Kinase B Signaling" @default.
• W2016095843 cites W1502045029 @default.
• W2016095843 cites W1838901836 @default.
• W2016095843 cites W1897121500 @default.
• W2016095843 cites W1971521863 @default.
• W2016095843 cites W1973962935 @default.
• W2016095843 cites W1973994766 @default.
• W2016095843 cites W1979565452 @default.
• W2016095843 cites W1985924323 @default.
• W2016095843 cites W1988022480 @default.
• W2016095843 cites W1997197477 @default.
• W2016095843 cites W1998641915 @default.
• W2016095843 cites W2000773502 @default.
• W2016095843 cites W2004001144 @default.
• W2016095843 cites W2013045396 @default.
• W2016095843 cites W2021484735 @default.
• W2016095843 cites W2023189554 @default.
• W2016095843 cites W2030541266 @default.
• W2016095843 cites W2041190857 @default.
• W2016095843 cites W2046148841 @default.
• W2016095843 cites W2049473983 @default.
• W2016095843 cites W2062834655 @default.
• W2016095843 cites W2063162933 @default.
• W2016095843 cites W2064378491 @default.
• W2016095843 cites W2071130401 @default.
• W2016095843 cites W2082479412 @default.
• W2016095843 cites W2082627499 @default.
• W2016095843 cites W2089800627 @default.
• W2016095843 cites W2098114704 @default.
• W2016095843 cites W2104320396 @default.
• W2016095843 cites W2110795584 @default.
• W2016095843 cites W2120027464 @default.
• W2016095843 cites W2125812283 @default.
• W2016095843 cites W2126029539 @default.
• W2016095843 cites W2132524533 @default.
• W2016095843 cites W2132740988 @default.
• W2016095843 cites W2134222140 @default.
• W2016095843 cites W2137709112 @default.
• W2016095843 cites W2139457018 @default.
• W2016095843 cites W2142535641 @default.
• W2016095843 cites W2158705348 @default.
• W2016095843 cites W2161170571 @default.
• W2016095843 cites W2164452916 @default.
• W2016095843 cites W2172342370 @default.
• W2016095843 doi "https://doi.org/10.1371/journal.pone.0041049" @default.
• W2016095843 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3402458" @default.
• W2016095843 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22911740" @default.
• W2016095843 hasPublicationYear "2012" @default.
• W2016095843 type Work @default.
• W2016095843 sameAs 2016095843 @default.
• W2016095843 citedByCount "17" @default.
• W2016095843 countsByYear W20160958432013 @default.
• W2016095843 countsByYear W20160958432015 @default.
• W2016095843 countsByYear W20160958432017 @default.
• W2016095843 countsByYear W20160958432018 @default.
• W2016095843 countsByYear W20160958432019 @default.
• W2016095843 countsByYear W20160958432020 @default.
• W2016095843 countsByYear W20160958432021 @default.
• W2016095843 countsByYear W20160958432022 @default.
• W2016095843 countsByYear W20160958432023 @default.
• W2016095843 crossrefType "journal-article" @default.
• W2016095843 hasAuthorship W2016095843A5014932121 @default.
• W2016095843 hasAuthorship W2016095843A5032344243 @default.
• W2016095843 hasAuthorship W2016095843A5048430036 @default.
• W2016095843 hasAuthorship W2016095843A5068095097 @default.
• W2016095843 hasAuthorship W2016095843A5080550942 @default.
• W2016095843 hasAuthorship W2016095843A5090160787 @default.
• W2016095843 hasBestOaLocation W20160958431 @default.
• W2016095843 hasConcept C134139212 @default.
• W2016095843 hasConcept C160539049 @default.
• W2016095843 hasConcept C170493617 @default.
• W2016095843 hasConcept C190283241 @default.
• W2016095843 hasConcept C2775975398 @default.
• W2016095843 hasConcept C42362537 @default.
• W2016095843 hasConcept C502942594 @default.
• W2016095843 hasConcept C55493867 @default.
• W2016095843 hasConcept C62112901 @default.
• W2016095843 hasConcept C62478195 @default.
• W2016095843 hasConcept C86803240 @default.
• W2016095843 hasConcept C92020748 @default.
• W2016095843 hasConcept C95444343 @default.
• W2016095843 hasConcept C97124661 @default.
• W2016095843 hasConceptScore W2016095843C134139212 @default.
• W2016095843 hasConceptScore W2016095843C160539049 @default.
• W2016095843 hasConceptScore W2016095843C170493617 @default.
• W2016095843 hasConceptScore W2016095843C190283241 @default.
• W2016095843 hasConceptScore W2016095843C2775975398 @default.
• W2016095843 hasConceptScore W2016095843C42362537 @default.

• next