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• W2016096976 abstract "Calorie restriction (CR) is the most robust intervention that decreases morbidity and mortality, and thereby increases the lifespan of many organisms. Although the signaling pathways involved in the beneficial effects of CR are not yet fully understood. Several candidate pathways and key molecules have been identified. The effects of CR are highly conserved from lower organisms such as yeast to higher mammals such as rodents and monkeys. Recent studies have also demonstrated beneficial effects of CR in humans, although we need much longer studies to evaluate whether CR also increases the lifespan of humans. In reality, it is difficult for us to conduct CR interventions in humans because the subjects must be kept in a state of hunger and the duration of this state needed to achieve a clinically meaningful effect is still unknown. Thus, research in this field is focusing on the development of molecules that mimic the beneficial effects of CR without reducing food intake. Some of these candidate molecules include plant-derived functional chemicals (phytochemicals), synthetic small molecules, and endocrine molecules such as adipokines. Several studies have already shown that this research field may yield novel drugs for the treatment of age-related diseases such as diabetes. In this article, we describe the target pathways, candidate molecules, and strategies to develop CR mimetics. Keywords: Biosensing, calorie restriction, cancer, drug discovery, metabolism, neurodegeneration, leptin, –, neuropeptide, hydroepiandrosterone sulfate, CALERIE, Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy, Metformin, liver kinase B1, adenosine monophosphate, Adipokines, NPY, rapamycin, TOR, Resveratrol, SIRT1, Sir2, CRISP, CR-Imitating agent Screening Platform" @default.
• W2016096976 created "2016-06-24" @default.
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• W2016096976 date "2010-12-01" @default.
• W2016096976 modified "2023-10-17" @default.
• W2016096976 title "Development of Calorie Restriction Mimetics as Therapeutics for Obesity, Diabetes, Inflammatory and Neurodegenerative Diseases" @default.
• W2016096976 cites W1616806865 @default.
• W2016096976 cites W1965414585 @default.
• W2016096976 cites W1971228310 @default.
• W2016096976 cites W1977043983 @default.
• W2016096976 cites W1978383432 @default.
• W2016096976 cites W1991096049 @default.
• W2016096976 cites W1992823976 @default.
• W2016096976 cites W1993132387 @default.
• W2016096976 cites W1994305081 @default.
• W2016096976 cites W1998833159 @default.
• W2016096976 cites W2002741326 @default.
• W2016096976 cites W2007664453 @default.
• W2016096976 cites W2009435453 @default.
• W2016096976 cites W2010238890 @default.
• W2016096976 cites W2013749723 @default.
• W2016096976 cites W2014892893 @default.
• W2016096976 cites W2017483828 @default.
• W2016096976 cites W2019152336 @default.
• W2016096976 cites W2022267544 @default.
• W2016096976 cites W2023203244 @default.
• W2016096976 cites W2026044755 @default.
• W2016096976 cites W2027976521 @default.
• W2016096976 cites W2029094968 @default.
• W2016096976 cites W2030031350 @default.
• W2016096976 cites W2037703570 @default.
• W2016096976 cites W2045201133 @default.
• W2016096976 cites W2048376025 @default.
• W2016096976 cites W2051509673 @default.
• W2016096976 cites W2051762464 @default.
• W2016096976 cites W2057416799 @default.
• W2016096976 cites W2060814375 @default.
• W2016096976 cites W2061684121 @default.
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• W2016096976 cites W2082067798 @default.
• W2016096976 cites W2084908610 @default.
• W2016096976 cites W2087761054 @default.
• W2016096976 cites W2088381487 @default.
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• W2016096976 doi "https://doi.org/10.2174/138920210793360934" @default.
• W2016096976 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3078680" @default.
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