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- W2016097009 abstract "The objective was to determine the effect of adrenocorticotropin (ACTH 1–17) on the incorporation of [3H]TdR into DNA (DNA synthesis) in the tongue, esophagus and stomach of CD2F1 mice standardized to 12 hours of light alternating with 12 hours of darkness. A question asked was whether the time of administration along the 24-hour time scale influenced any response found. The response was complex as ACTH 1–17 was capable of bringing about statistically significant increases in the incorporation of [3H]TdR into DNA at certain times, decreases at other times, or no response at still another time. In general the most marked effects of 20 IU/kg of ACTH 1–17 when compared to controls, was to decrease DNA synthesis of as much as 60% 4 hours after administration at the end of the dark or begining of the light span. A 2- and 3-way analysis of variance supported the conclusion that the kind-of-treatment, time-of-treatment and the interval-to-kill (Sampling time) as well as their interactions are important factors when determining any response of ACTH 1–17 or placebo." @default.
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- W2016097009 date "1984-05-01" @default.
- W2016097009 modified "2023-10-18" @default.
- W2016097009 title "Effect of ACTH 1–17 at different circadian stages on [3H]TdR incorporation into DNA" @default.
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- W2016097009 doi "https://doi.org/10.1016/0196-9781(84)90079-2" @default.
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