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- W2016097343 abstract "Ultraviolet irradiation of DNA produces cytosine hydrate, released as a free base by E. coli endonuclease Ill. Cytosine hydrate excision was investigated by assaying photoproduct release from cytosine-radiolabeled, irradiated poly(dG-dC):poly(dGdC). Conformational shifts between B-DNA and 2-DNA were effected by heating the polymer in either nickel chloride or cobaltous chloride, and were determined by circular dichroism. Rates of enzymic cytosine hydrate release did not differ between the different substrate conformations. Irradiation of left-handed poly(dG-dC):poly(dG-dC) resulted in cytosine hydrate formation. Therefore, neither formation nor enzymic excision of ultraviolet-induced cytosine hydrates are substantially affected by these DNA conformational states." @default.
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- W2016097343 date "1990-01-01" @default.
- W2016097343 modified "2023-09-27" @default.
- W2016097343 title "Excision of cytosine hydrates from Z-DNA" @default.
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- W2016097343 doi "https://doi.org/10.1093/nar/18.8.2007" @default.
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