FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016097851> ?p ?o ?g. }

• W2016097851 endingPage "222" @default.
• W2016097851 startingPage "216" @default.
• W2016097851 abstract "The harmony and function of the complex brain circuits and synapses are sustained mainly by excitatory and inhibitory neurotransmission, neurotrophins, gene regulation, and factors, many of which are incompletely understood. A common feature of brain circuit components, such as dendrites, synaptic membranes, and other membranes of the nervous system, is that they are richly endowed in docosahexaenoic acid (DHA), the main member of the omega-3 essential fatty acid family. DHA is avidly retained and concentrated in the nervous system and known to play a role in neuroprotection, memory, and vision. Only recently has it become apparent why the surprisingly rapid increases in free (unesterified) DHA pool size take place at the onset of seizures or brain injury. This phenomenon began to be clarified by the discovery of neuroprotectin D1 (NPD1), the first-uncovered bioactive docosanoid formed from free DHA through 15-lipoxygenase-1 (15-LOX-1). NPD1 synthesis includes, as agonists, oxidative stress and neurotrophins. The evolving concept is that DHA-derived docosanoids set in motion endogenous signaling to sustain homeostatic synaptic and circuit integrity. NPD1 is anti-inflammatory, displays inflammatory resolving activities, and induces cell survival, which is in contrast to the pro-inflammatory actions of the many of omega-6 fatty acid family members. We highlight here studies relevant to the ability of DHA to sustain neuronal function and protect synapses and circuits in the context of DHA signalolipidomics. DHA signalolipidomics comprises the integration of the cellular/tissue mechanism of DHA uptake, its distribution among cellular compartments, the organization and function of membrane domains containing DHA phospholipids, and the precise cellular and molecular events revealed by the uncovering of signaling pathways regulated by docosanoids endowed with prohomeostatic and cell survival bioactivity. Therefore, this approach offers emerging targets for prevention, pharmaceutical intervention, and clinical translation involving DHA-mediated signaling." @default.
• W2016097851 created "2016-06-24" @default.
• W2016097851 creator A5041296572 @default.
• W2016097851 creator A5068398524 @default.
• W2016097851 creator A5074826931 @default.
• W2016097851 date "2011-09-15" @default.
• W2016097851 modified "2023-10-14" @default.
• W2016097851 title "Endogenous Signaling by Omega-3 Docosahexaenoic Acid-derived Mediators Sustains Homeostatic Synaptic and Circuitry Integrity" @default.
• W2016097851 cites W1480035757 @default.
• W2016097851 cites W1557261649 @default.
• W2016097851 cites W1577144537 @default.
• W2016097851 cites W1739691545 @default.
• W2016097851 cites W1875781283 @default.
• W2016097851 cites W1891888434 @default.
• W2016097851 cites W1916017797 @default.
• W2016097851 cites W196459055 @default.
• W2016097851 cites W1964721333 @default.
• W2016097851 cites W1965555619 @default.
• W2016097851 cites W1969871031 @default.
• W2016097851 cites W1983755623 @default.
• W2016097851 cites W1990950703 @default.
• W2016097851 cites W1991084221 @default.
• W2016097851 cites W1999709357 @default.
• W2016097851 cites W2001025314 @default.
• W2016097851 cites W2005293673 @default.
• W2016097851 cites W2005390270 @default.
• W2016097851 cites W2010306979 @default.
• W2016097851 cites W2015900627 @default.
• W2016097851 cites W2022004671 @default.
• W2016097851 cites W2029253850 @default.
• W2016097851 cites W2035247886 @default.
• W2016097851 cites W2039427231 @default.
• W2016097851 cites W2041895791 @default.
• W2016097851 cites W2049617752 @default.
• W2016097851 cites W2052839739 @default.
• W2016097851 cites W2057128909 @default.
• W2016097851 cites W2062659934 @default.
• W2016097851 cites W2063123880 @default.
• W2016097851 cites W2064884954 @default.
• W2016097851 cites W2066134397 @default.
• W2016097851 cites W2066976637 @default.
• W2016097851 cites W2076269247 @default.
• W2016097851 cites W2089100905 @default.
• W2016097851 cites W2090504233 @default.
• W2016097851 cites W2091618023 @default.
• W2016097851 cites W2100726346 @default.
• W2016097851 cites W2115558180 @default.
• W2016097851 cites W2130852003 @default.
• W2016097851 cites W2139602837 @default.
• W2016097851 cites W2141720672 @default.
• W2016097851 cites W2143187099 @default.
• W2016097851 cites W2145260966 @default.
• W2016097851 cites W2148602524 @default.
• W2016097851 cites W2152208311 @default.
• W2016097851 cites W2157340973 @default.
• W2016097851 cites W2163837156 @default.
• W2016097851 cites W2168480206 @default.
• W2016097851 cites W4254019069 @default.
• W2016097851 doi "https://doi.org/10.1007/s12035-011-8200-6" @default.
• W2016097851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3180614" @default.
• W2016097851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21918832" @default.
• W2016097851 hasPublicationYear "2011" @default.
• W2016097851 type Work @default.
• W2016097851 sameAs 2016097851 @default.
• W2016097851 citedByCount "105" @default.
• W2016097851 countsByYear W20160978512012 @default.
• W2016097851 countsByYear W20160978512013 @default.
• W2016097851 countsByYear W20160978512014 @default.
• W2016097851 countsByYear W20160978512015 @default.
• W2016097851 countsByYear W20160978512016 @default.
• W2016097851 countsByYear W20160978512017 @default.
• W2016097851 countsByYear W20160978512018 @default.
• W2016097851 countsByYear W20160978512019 @default.
• W2016097851 countsByYear W20160978512020 @default.
• W2016097851 countsByYear W20160978512021 @default.
• W2016097851 countsByYear W20160978512022 @default.
• W2016097851 countsByYear W20160978512023 @default.
• W2016097851 crossrefType "journal-article" @default.
• W2016097851 hasAuthorship W2016097851A5041296572 @default.
• W2016097851 hasAuthorship W2016097851A5068398524 @default.
• W2016097851 hasAuthorship W2016097851A5074826931 @default.
• W2016097851 hasBestOaLocation W20160978511 @default.
• W2016097851 hasConcept C169760540 @default.
• W2016097851 hasConcept C170493617 @default.
• W2016097851 hasConcept C19038510 @default.
• W2016097851 hasConcept C200170125 @default.
• W2016097851 hasConcept C25498285 @default.
• W2016097851 hasConcept C2777171753 @default.
• W2016097851 hasConcept C543025807 @default.
• W2016097851 hasConcept C545706735 @default.
• W2016097851 hasConcept C55493867 @default.
• W2016097851 hasConcept C86803240 @default.
• W2016097851 hasConcept C95444343 @default.
• W2016097851 hasConceptScore W2016097851C169760540 @default.
• W2016097851 hasConceptScore W2016097851C170493617 @default.
• W2016097851 hasConceptScore W2016097851C19038510 @default.
• W2016097851 hasConceptScore W2016097851C200170125 @default.
• W2016097851 hasConceptScore W2016097851C25498285 @default.

• next