FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016097990> ?p ?o ?g. }

• W2016097990 endingPage "2103" @default.
• W2016097990 startingPage "2096" @default.
• W2016097990 abstract "This paper demonstrates the generation of systemically deliverable layer-by-layer (LbL) nanoparticles for cancer applications. LbL-based nanoparticles designed to navigate the body and deliver therapeutics in a programmable fashion are promising new and alternative systems for drug delivery, but there have been very few demonstrations of their systemic delivery in vivo due to a lack of knowledge in building LbL nanofilms that mimic traditional nanoparticle design to optimize delivery. The key to the successful application of these nanocarriers in vivo requires a systematic analysis of the influence of film architecture and adsorbed polyelectrolyte outer layer on their pharmacokinetics, which has thus far not been examined for this new approach to nanoparticle delivery. Herein, we have taken the first steps in stabilizing and controlling the systemic distribution of multilayer nanoparticles. Our findings highlight the unique character of LbL systems; the electrostatically assembled nanoparticles gain increased stability in vivo with larger numbers of deposited layers, and the final layer adsorbed generates a critical surface cascade, which dictates the surface chemistry and biological properties of the nanoparticle. This outer polyelectrolyte layer dramatically affects not only the degree of nonspecific particle uptake, but also the nanoparticle biodistribution. For hyaluronic acid (HA) outer layers, a long blood elimination half-life (∼9 h) and low accumulation (∼10-15% recovered fluorescence/g) in the liver were observed, illustrating that these systems can be designed to be highly appropriate for clinical translation." @default.
• W2016097990 created "2016-06-24" @default.
• W2016097990 creator A5017048432 @default.
• W2016097990 creator A5044863888 @default.
• W2016097990 creator A5069094503 @default.
• W2016097990 creator A5087726409 @default.
• W2016097990 date "2011-05-11" @default.
• W2016097990 modified "2023-09-30" @default.
• W2016097990 title "Controlling in Vivo Stability and Biodistribution in Electrostatically Assembled Nanoparticles for Systemic Delivery" @default.
• W2016097990 cites W148863560 @default.
• W2016097990 cites W1542991256 @default.
• W2016097990 cites W1968061953 @default.
• W2016097990 cites W1969233927 @default.
• W2016097990 cites W1973647610 @default.
• W2016097990 cites W1975088956 @default.
• W2016097990 cites W1975670424 @default.
• W2016097990 cites W1978654303 @default.
• W2016097990 cites W1982505831 @default.
• W2016097990 cites W1990008082 @default.
• W2016097990 cites W1993776480 @default.
• W2016097990 cites W2002516695 @default.
• W2016097990 cites W2004113260 @default.
• W2016097990 cites W2008875519 @default.
• W2016097990 cites W2012208245 @default.
• W2016097990 cites W2013470095 @default.
• W2016097990 cites W2013930572 @default.
• W2016097990 cites W2019555018 @default.
• W2016097990 cites W2024787650 @default.
• W2016097990 cites W2028573860 @default.
• W2016097990 cites W2030855909 @default.
• W2016097990 cites W2038444068 @default.
• W2016097990 cites W2043120353 @default.
• W2016097990 cites W2046380234 @default.
• W2016097990 cites W2047354583 @default.
• W2016097990 cites W2056560999 @default.
• W2016097990 cites W2064093384 @default.
• W2016097990 cites W2064614508 @default.
• W2016097990 cites W2064848737 @default.
• W2016097990 cites W2076349775 @default.
• W2016097990 cites W2095459200 @default.
• W2016097990 cites W2116334397 @default.
• W2016097990 cites W2129077285 @default.
• W2016097990 cites W2145786098 @default.
• W2016097990 cites W2151758317 @default.
• W2016097990 cites W2164392244 @default.
• W2016097990 cites W2165210975 @default.
• W2016097990 doi "https://doi.org/10.1021/nl200636r" @default.
• W2016097990 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3124010" @default.
• W2016097990 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21524115" @default.
• W2016097990 hasPublicationYear "2011" @default.
• W2016097990 type Work @default.
• W2016097990 sameAs 2016097990 @default.
• W2016097990 citedByCount "170" @default.
• W2016097990 countsByYear W20160979902012 @default.
• W2016097990 countsByYear W20160979902013 @default.
• W2016097990 countsByYear W20160979902014 @default.
• W2016097990 countsByYear W20160979902015 @default.
• W2016097990 countsByYear W20160979902016 @default.
• W2016097990 countsByYear W20160979902017 @default.
• W2016097990 countsByYear W20160979902018 @default.
• W2016097990 countsByYear W20160979902019 @default.
• W2016097990 countsByYear W20160979902020 @default.
• W2016097990 countsByYear W20160979902021 @default.
• W2016097990 countsByYear W20160979902022 @default.
• W2016097990 countsByYear W20160979902023 @default.
• W2016097990 crossrefType "journal-article" @default.
• W2016097990 hasAuthorship W2016097990A5017048432 @default.
• W2016097990 hasAuthorship W2016097990A5044863888 @default.
• W2016097990 hasAuthorship W2016097990A5069094503 @default.
• W2016097990 hasAuthorship W2016097990A5087726409 @default.
• W2016097990 hasBestOaLocation W20160979902 @default.
• W2016097990 hasConcept C115537861 @default.
• W2016097990 hasConcept C147789679 @default.
• W2016097990 hasConcept C150903083 @default.
• W2016097990 hasConcept C153356533 @default.
• W2016097990 hasConcept C155672457 @default.
• W2016097990 hasConcept C159985019 @default.
• W2016097990 hasConcept C171250308 @default.
• W2016097990 hasConcept C18150654 @default.
• W2016097990 hasConcept C185592680 @default.
• W2016097990 hasConcept C192562407 @default.
• W2016097990 hasConcept C207001950 @default.
• W2016097990 hasConcept C2777807558 @default.
• W2016097990 hasConcept C2779820397 @default.
• W2016097990 hasConcept C521977710 @default.
• W2016097990 hasConcept C86803240 @default.
• W2016097990 hasConceptScore W2016097990C115537861 @default.
• W2016097990 hasConceptScore W2016097990C147789679 @default.
• W2016097990 hasConceptScore W2016097990C150903083 @default.
• W2016097990 hasConceptScore W2016097990C153356533 @default.
• W2016097990 hasConceptScore W2016097990C155672457 @default.
• W2016097990 hasConceptScore W2016097990C159985019 @default.
• W2016097990 hasConceptScore W2016097990C171250308 @default.
• W2016097990 hasConceptScore W2016097990C18150654 @default.
• W2016097990 hasConceptScore W2016097990C185592680 @default.
• W2016097990 hasConceptScore W2016097990C192562407 @default.
• W2016097990 hasConceptScore W2016097990C207001950 @default.
• W2016097990 hasConceptScore W2016097990C2777807558 @default.

• next