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• W2016099287 abstract "Background Dialysis patients are classified according to their peritoneal permeability as low transporter (LT, low solute permeability) or high transporter (HT, high solute permeability). Tight junction (TJ) proteins are critical to maintain ions, molecules and water paracellular transport through peritoneum. Exposure to peritoneal dialysis solutions causes damage to TJ in human peritoneal mesothelial cells (HPMCs). We analyzed the quantity, distribution and function of TJ proteins: claudin-1, -2 and -8, ZO-1 and occludin, in HPMC cultures from LT and HT patients. Since all-trans retinoic acid (ATRA) might modify the expression of TJ proteins, we studied its effect on HPMCs. Methods Control HPMCs were isolated from human omentum, while HT or LT cells were obtained from dialysis effluents. Cells were cultured in presence of ATRA 0, 50 or 100 nM. Transepithelial electrical resistance (TER) measurement, immunostaining and Western blot analyses were performed. Results HT exhibited lower TER than control and LT monolayers. Immunofluorescence for TJ was weak and discontinuous along the cell contour, in LT and HT. Furthermore, claudin- 1, occludin and ZO-1 expressions were decreased. In all groups, claudin-2 was localized at nuclei. We observed that ATRA improved TJ distribution and increased TJ expression in HT. This retinoid did not modify claudin-2 and -8 expressions. All-trans retinoic acid decreased TER in HT, but had no effect in LT. Conclusions Tight junctions were altered in HPMCs from dialyzed patients. The HT monolayer has lower TER than LT, which might be associated with the peritoneal permeability in these patients. ATRA might be a therapeutic alternative to maintain mesothelial integrity, since it improved TJ localization and expression." @default.
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• W2016099287 date "2015-05-01" @default.
• W2016099287 modified "2023-09-26" @default.
• W2016099287 title "Alterations of Intercellular Junctions in Peritoneal Mesothelial Cells from Patients Undergoing Dialysis: Effect of Retinoic Acid" @default.
• W2016099287 cites W1729818254 @default.
• W2016099287 cites W1850146802 @default.
• W2016099287 cites W1856257838 @default.
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• W2016099287 cites W1972484042 @default.
• W2016099287 cites W1976839673 @default.
• W2016099287 cites W1988520676 @default.
• W2016099287 cites W1997365253 @default.
• W2016099287 cites W1999132350 @default.
• W2016099287 cites W2004723568 @default.
• W2016099287 cites W2012428888 @default.
• W2016099287 cites W2012565034 @default.
• W2016099287 cites W2012931815 @default.
• W2016099287 cites W2022535515 @default.
• W2016099287 cites W2022889989 @default.
• W2016099287 cites W2040392762 @default.
• W2016099287 cites W2047316900 @default.
• W2016099287 cites W2053326916 @default.
• W2016099287 cites W2055007053 @default.
• W2016099287 cites W2056425629 @default.
• W2016099287 cites W2061387619 @default.
• W2016099287 cites W2061418256 @default.
• W2016099287 cites W2068902736 @default.
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• W2016099287 cites W2074307439 @default.
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• W2016099287 cites W2127296894 @default.
• W2016099287 cites W2131886220 @default.
• W2016099287 cites W2138365237 @default.
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• W2016099287 doi "https://doi.org/10.3747/pdi.2012.00323" @default.
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