FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016105549> ?p ?o ?g. }

• W2016105549 endingPage "7323" @default.
• W2016105549 startingPage "7311" @default.
• W2016105549 abstract "With annual death tolls in the millions and emerging resistance to existing drugs, novel therapies are needed against malaria. Wiesner et al. recently developed a novel class of antimalarials derived from farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold. The compounds displayed a wide range of activity, including submicromolar, against the multi-drug resistant Plasmodium falciparum strain Dd2. In order to investigate quantitatively the local physicochemical properties involved in the interaction between drug and biotarget, we used the 3D-QSAR methods CoMFA and CoMSIA to study some of the series, including the screened lead compound 2,5-bis-acylaminobenzophenone, 28 cinnamic acid derivatives, 29 N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides, and 34 N-(4-substituted-amino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides. We found that steric, electrostatic, and hydrophobic properties of substituent groups play key roles in the bioactivity of the series of compounds, while hydrogen bonding interactions show no obvious impact. We built several highly predictive 3D-QSAR models, including a CoMSIA one composed of steric, electrostatic, and hydrophobic fields, with r(2)=0.94, q(2)=0.63, and r(pred)(2)=0.63. The results provide insight for optimization of this class of antimalarials for better activity and may prove helpful for further lead optimization." @default.
• W2016105549 created "2016-06-24" @default.
• W2016105549 creator A5013748007 @default.
• W2016105549 creator A5055907201 @default.
• W2016105549 creator A5069475650 @default.
• W2016105549 date "2006-11-01" @default.
• W2016105549 modified "2023-10-14" @default.
• W2016105549 title "3D-QSAR analysis of antimalarial farnesyltransferase inhibitors based on a 2,5-diaminobenzophenone scaffold" @default.
• W2016105549 cites W1974911216 @default.
• W2016105549 cites W1975759746 @default.
• W2016105549 cites W1982716068 @default.
• W2016105549 cites W1982837617 @default.
• W2016105549 cites W1988771765 @default.
• W2016105549 cites W1994835881 @default.
• W2016105549 cites W1995064146 @default.
• W2016105549 cites W2004397427 @default.
• W2016105549 cites W2008116313 @default.
• W2016105549 cites W2010926985 @default.
• W2016105549 cites W2015928143 @default.
• W2016105549 cites W2018182528 @default.
• W2016105549 cites W2023095398 @default.
• W2016105549 cites W2026610312 @default.
• W2016105549 cites W2029949214 @default.
• W2016105549 cites W2033634323 @default.
• W2016105549 cites W2033686988 @default.
• W2016105549 cites W2035400279 @default.
• W2016105549 cites W2038030353 @default.
• W2016105549 cites W2040351166 @default.
• W2016105549 cites W2043645060 @default.
• W2016105549 cites W2057800906 @default.
• W2016105549 cites W2058070161 @default.
• W2016105549 cites W2063060349 @default.
• W2016105549 cites W2063906760 @default.
• W2016105549 cites W2065374870 @default.
• W2016105549 cites W2066829425 @default.
• W2016105549 cites W2067428749 @default.
• W2016105549 cites W2080120147 @default.
• W2016105549 cites W2081216189 @default.
• W2016105549 cites W2082080415 @default.
• W2016105549 cites W2089906643 @default.
• W2016105549 cites W2101098292 @default.
• W2016105549 cites W2102155970 @default.
• W2016105549 cites W2108247214 @default.
• W2016105549 cites W2114407163 @default.
• W2016105549 cites W2115862194 @default.
• W2016105549 cites W2116864669 @default.
• W2016105549 cites W2120048621 @default.
• W2016105549 cites W2129676237 @default.
• W2016105549 cites W2169812632 @default.
• W2016105549 cites W2172786051 @default.
• W2016105549 cites W2175531508 @default.
• W2016105549 cites W2177410728 @default.
• W2016105549 cites W2212567822 @default.
• W2016105549 cites W4231620004 @default.
• W2016105549 cites W4232172419 @default.
• W2016105549 doi "https://doi.org/10.1016/j.bmc.2006.06.041" @default.
• W2016105549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16837204" @default.
• W2016105549 hasPublicationYear "2006" @default.
• W2016105549 type Work @default.
• W2016105549 sameAs 2016105549 @default.
• W2016105549 citedByCount "20" @default.
• W2016105549 countsByYear W20161055492012 @default.
• W2016105549 countsByYear W20161055492013 @default.
• W2016105549 countsByYear W20161055492014 @default.
• W2016105549 countsByYear W20161055492015 @default.
• W2016105549 countsByYear W20161055492019 @default.
• W2016105549 countsByYear W20161055492022 @default.
• W2016105549 crossrefType "journal-article" @default.
• W2016105549 hasAuthorship W2016105549A5013748007 @default.
• W2016105549 hasAuthorship W2016105549A5055907201 @default.
• W2016105549 hasAuthorship W2016105549A5069475650 @default.
• W2016105549 hasConcept C112887158 @default.
• W2016105549 hasConcept C164126121 @default.
• W2016105549 hasConcept C178790620 @default.
• W2016105549 hasConcept C181199279 @default.
• W2016105549 hasConcept C185592680 @default.
• W2016105549 hasConcept C201194858 @default.
• W2016105549 hasConcept C202751555 @default.
• W2016105549 hasConcept C203014093 @default.
• W2016105549 hasConcept C21951064 @default.
• W2016105549 hasConcept C2777752112 @default.
• W2016105549 hasConcept C2778048844 @default.
• W2016105549 hasConcept C2778371730 @default.
• W2016105549 hasConcept C2778396349 @default.
• W2016105549 hasConcept C2778689049 @default.
• W2016105549 hasConcept C2908859342 @default.
• W2016105549 hasConcept C32909587 @default.
• W2016105549 hasConcept C55493867 @default.
• W2016105549 hasConcept C57790582 @default.
• W2016105549 hasConcept C71240020 @default.
• W2016105549 hasConcept C86803240 @default.
• W2016105549 hasConcept C90260826 @default.
• W2016105549 hasConceptScore W2016105549C112887158 @default.
• W2016105549 hasConceptScore W2016105549C164126121 @default.
• W2016105549 hasConceptScore W2016105549C178790620 @default.
• W2016105549 hasConceptScore W2016105549C181199279 @default.
• W2016105549 hasConceptScore W2016105549C185592680 @default.
• W2016105549 hasConceptScore W2016105549C201194858 @default.

• next