Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016109189> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2016109189 endingPage "99" @default.
- W2016109189 startingPage "94" @default.
- W2016109189 abstract "The effects of Mg(2+) and K(+) ions on the self-splicing inhibition of the td (thymidylate synthase gene) intron RNA by spectinomycin were investigated. The maximum splicing activity occurred at 20 mM KCl. The K(m) and V(max) values for GTP in the presence of 5 mM Mg(2+) are 2.25 microM and 0.55 min(-1), whereas those for GTP both in the presence of 5 mM Mg(2+) and 5 mM K(+) are 1.23 microM and 0. 46 min(-1), respectively. Spectinomycin at 10 mM concentration inhibited the splicing by about 10%, but at 20 mM concentration, the splicing rate was inhibited by about 63%. The splicing inhibition by the low concentration of spectinomycin was overcome markedly as the concentration of Mg(2+) ion was raised. At 30 mM spectinomycin, however, the splicing inhibition was not significantly affected by increasing the concentration of Mg(2+). A similar activation of the splicing rate was observed as the concentration of K(+) ion was increased. The concentration of K(+) ion required for the normal recovery of the splicing was much higher than that of Mg(2+) ion. Unlike Mg(2+) ion, 30 mM K(+) ion effectively alleviated the splicing inhibition by spectinomycin at its high concentration. The results indicate that K(+) and Mg(2+) ions may show mechanistically different interactions with spectinomycin in the self-splicing reaction of the td intron RNA." @default.
- W2016109189 created "2016-06-24" @default.
- W2016109189 creator A5040028568 @default.
- W2016109189 creator A5081844315 @default.
- W2016109189 date "2000-06-01" @default.
- W2016109189 modified "2023-09-27" @default.
- W2016109189 title "K+ and Mg2+ ions promote the self-splicing of the td intron RNA inhibited by spectinomycin" @default.
- W2016109189 cites W1587658095 @default.
- W2016109189 cites W1964915470 @default.
- W2016109189 cites W1968809805 @default.
- W2016109189 cites W1972137957 @default.
- W2016109189 cites W1975744482 @default.
- W2016109189 cites W1978847377 @default.
- W2016109189 cites W2002653581 @default.
- W2016109189 cites W2003201962 @default.
- W2016109189 cites W2005064067 @default.
- W2016109189 cites W2012883963 @default.
- W2016109189 cites W2024957115 @default.
- W2016109189 cites W2035546741 @default.
- W2016109189 cites W2035789145 @default.
- W2016109189 cites W2044494337 @default.
- W2016109189 cites W2051281883 @default.
- W2016109189 cites W2052918841 @default.
- W2016109189 cites W2055886104 @default.
- W2016109189 cites W2062911181 @default.
- W2016109189 cites W2066341819 @default.
- W2016109189 cites W2081291394 @default.
- W2016109189 cites W2090659763 @default.
- W2016109189 cites W2107578842 @default.
- W2016109189 cites W2139477511 @default.
- W2016109189 cites W2269961526 @default.
- W2016109189 doi "https://doi.org/10.1016/s0167-4781(00)00088-9" @default.
- W2016109189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10858535" @default.
- W2016109189 hasPublicationYear "2000" @default.
- W2016109189 type Work @default.
- W2016109189 sameAs 2016109189 @default.
- W2016109189 citedByCount "6" @default.
- W2016109189 crossrefType "journal-article" @default.
- W2016109189 hasAuthorship W2016109189A5040028568 @default.
- W2016109189 hasAuthorship W2016109189A5081844315 @default.
- W2016109189 hasConcept C104317684 @default.
- W2016109189 hasConcept C12554922 @default.
- W2016109189 hasConcept C145148216 @default.
- W2016109189 hasConcept C153911025 @default.
- W2016109189 hasConcept C166342232 @default.
- W2016109189 hasConcept C178790620 @default.
- W2016109189 hasConcept C185592680 @default.
- W2016109189 hasConcept C2778063948 @default.
- W2016109189 hasConcept C501593827 @default.
- W2016109189 hasConcept C54458228 @default.
- W2016109189 hasConcept C55493867 @default.
- W2016109189 hasConcept C67705224 @default.
- W2016109189 hasConcept C86803240 @default.
- W2016109189 hasConcept C94665300 @default.
- W2016109189 hasConcept C94671646 @default.
- W2016109189 hasConceptScore W2016109189C104317684 @default.
- W2016109189 hasConceptScore W2016109189C12554922 @default.
- W2016109189 hasConceptScore W2016109189C145148216 @default.
- W2016109189 hasConceptScore W2016109189C153911025 @default.
- W2016109189 hasConceptScore W2016109189C166342232 @default.
- W2016109189 hasConceptScore W2016109189C178790620 @default.
- W2016109189 hasConceptScore W2016109189C185592680 @default.
- W2016109189 hasConceptScore W2016109189C2778063948 @default.
- W2016109189 hasConceptScore W2016109189C501593827 @default.
- W2016109189 hasConceptScore W2016109189C54458228 @default.
- W2016109189 hasConceptScore W2016109189C55493867 @default.
- W2016109189 hasConceptScore W2016109189C67705224 @default.
- W2016109189 hasConceptScore W2016109189C86803240 @default.
- W2016109189 hasConceptScore W2016109189C94665300 @default.
- W2016109189 hasConceptScore W2016109189C94671646 @default.
- W2016109189 hasIssue "1" @default.
- W2016109189 hasLocation W20161091891 @default.
- W2016109189 hasLocation W20161091892 @default.
- W2016109189 hasOpenAccess W2016109189 @default.
- W2016109189 hasPrimaryLocation W20161091891 @default.
- W2016109189 hasRelatedWork W2016109189 @default.
- W2016109189 hasRelatedWork W2017923526 @default.
- W2016109189 hasRelatedWork W2073554211 @default.
- W2016109189 hasRelatedWork W2094458176 @default.
- W2016109189 hasRelatedWork W2109736541 @default.
- W2016109189 hasRelatedWork W2120243182 @default.
- W2016109189 hasRelatedWork W2124091487 @default.
- W2016109189 hasRelatedWork W2808425697 @default.
- W2016109189 hasRelatedWork W2951406376 @default.
- W2016109189 hasRelatedWork W4242042731 @default.
- W2016109189 hasVolume "1492" @default.
- W2016109189 isParatext "false" @default.
- W2016109189 isRetracted "false" @default.
- W2016109189 magId "2016109189" @default.
- W2016109189 workType "article" @default.