FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016110231> ?p ?o ?g. }

• W2016110231 endingPage "961" @default.
• W2016110231 startingPage "951" @default.
• W2016110231 abstract "Coiled coils are important structural motifs formed by two or more amphipathic α-helices that twist into a supercoil. These motifs are found in a wide range of proteins, including motor proteins and structural proteins, that are known to transmit mechanical loads. We analyze atomically detailed simulations of coiled-coil cracking under load with Milestoning. Milestoning is an approach that captures the main features of the process in a network, quantifying kinetics and thermodynamics. A 112-residue segment of the β-myosin S2 domain was subjected to constant-magnitude (0-200 pN) and constant-direction tensile forces in molecular dynamics simulations. Twenty 20 ns straightforward simulations at several load levels revealed that initial single-residue cracking events (Ψ > 90°) at loads <100 pN were accompanied by rapid refolding without either intra- or interhelix unfolding propagation. Only initial unfolding events at the highest load (200 pN) regularly propagated along and between helices. Analysis of hydrophobic interactions and of interhelix hydrogen bonds did not show significant variation as a function of load. Unfolding events were overwhelmingly located in the vicinity of E929, a charged residue in a hydrophobic position of the heptad repeat. Milestoning network analysis of E929 cracking determined that the mean first-passage time ranges from 20 ns (200 pN) to 80 ns (50 pN), which is ∼20 times the mean first-passage time of an isolated helix with the same sequence." @default.
• W2016110231 created "2016-06-24" @default.
• W2016110231 creator A5032894561 @default.
• W2016110231 creator A5081349407 @default.
• W2016110231 date "2013-08-01" @default.
• W2016110231 modified "2023-10-16" @default.
• W2016110231 title "Coiled-Coil Response to Mechanical Force: Global Stability and Local Cracking" @default.
• W2016110231 cites W1963487371 @default.
• W2016110231 cites W1967531754 @default.
• W2016110231 cites W1974837363 @default.
• W2016110231 cites W1977751952 @default.
• W2016110231 cites W1978791588 @default.
• W2016110231 cites W1985936786 @default.
• W2016110231 cites W1989504189 @default.
• W2016110231 cites W1991051440 @default.
• W2016110231 cites W1996631886 @default.
• W2016110231 cites W2009528324 @default.
• W2016110231 cites W2014852739 @default.
• W2016110231 cites W2022276471 @default.
• W2016110231 cites W2025351437 @default.
• W2016110231 cites W2030029307 @default.
• W2016110231 cites W2042252336 @default.
• W2016110231 cites W2044300686 @default.
• W2016110231 cites W2044465352 @default.
• W2016110231 cites W2044677088 @default.
• W2016110231 cites W2053053599 @default.
• W2016110231 cites W2064556178 @default.
• W2016110231 cites W2065232574 @default.
• W2016110231 cites W2066083439 @default.
• W2016110231 cites W2068756855 @default.
• W2016110231 cites W2072591681 @default.
• W2016110231 cites W2073364361 @default.
• W2016110231 cites W2074412480 @default.
• W2016110231 cites W2084747396 @default.
• W2016110231 cites W2105451571 @default.
• W2016110231 cites W2116963688 @default.
• W2016110231 cites W2118238916 @default.
• W2016110231 cites W2124852145 @default.
• W2016110231 cites W2131759563 @default.
• W2016110231 cites W2136506290 @default.
• W2016110231 cites W2143300823 @default.
• W2016110231 cites W2149146343 @default.
• W2016110231 cites W2172219847 @default.
• W2016110231 cites W3098184811 @default.
• W2016110231 doi "https://doi.org/10.1016/j.bpj.2013.05.064" @default.
• W2016110231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3752098" @default.
• W2016110231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23972847" @default.
• W2016110231 hasPublicationYear "2013" @default.
• W2016110231 type Work @default.
• W2016110231 sameAs 2016110231 @default.
• W2016110231 citedByCount "22" @default.
• W2016110231 countsByYear W20161102312013 @default.
• W2016110231 countsByYear W20161102312014 @default.
• W2016110231 countsByYear W20161102312015 @default.
• W2016110231 countsByYear W20161102312016 @default.
• W2016110231 countsByYear W20161102312017 @default.
• W2016110231 countsByYear W20161102312018 @default.
• W2016110231 countsByYear W20161102312019 @default.
• W2016110231 countsByYear W20161102312020 @default.
• W2016110231 countsByYear W20161102312021 @default.
• W2016110231 countsByYear W20161102312023 @default.
• W2016110231 crossrefType "journal-article" @default.
• W2016110231 hasAuthorship W2016110231A5032894561 @default.
• W2016110231 hasAuthorship W2016110231A5081349407 @default.
• W2016110231 hasBestOaLocation W20161102311 @default.
• W2016110231 hasConcept C104317684 @default.
• W2016110231 hasConcept C121332964 @default.
• W2016110231 hasConcept C122146531 @default.
• W2016110231 hasConcept C12554922 @default.
• W2016110231 hasConcept C147597530 @default.
• W2016110231 hasConcept C148898269 @default.
• W2016110231 hasConcept C159467904 @default.
• W2016110231 hasConcept C167625842 @default.
• W2016110231 hasConcept C185592680 @default.
• W2016110231 hasConcept C192562407 @default.
• W2016110231 hasConcept C19472624 @default.
• W2016110231 hasConcept C206276672 @default.
• W2016110231 hasConcept C2524010 @default.
• W2016110231 hasConcept C2776196297 @default.
• W2016110231 hasConcept C33923547 @default.
• W2016110231 hasConcept C55493867 @default.
• W2016110231 hasConcept C59593255 @default.
• W2016110231 hasConcept C74650414 @default.
• W2016110231 hasConcept C8010536 @default.
• W2016110231 hasConcept C86803240 @default.
• W2016110231 hasConceptScore W2016110231C104317684 @default.
• W2016110231 hasConceptScore W2016110231C121332964 @default.
• W2016110231 hasConceptScore W2016110231C122146531 @default.
• W2016110231 hasConceptScore W2016110231C12554922 @default.
• W2016110231 hasConceptScore W2016110231C147597530 @default.
• W2016110231 hasConceptScore W2016110231C148898269 @default.
• W2016110231 hasConceptScore W2016110231C159467904 @default.
• W2016110231 hasConceptScore W2016110231C167625842 @default.
• W2016110231 hasConceptScore W2016110231C185592680 @default.
• W2016110231 hasConceptScore W2016110231C192562407 @default.
• W2016110231 hasConceptScore W2016110231C19472624 @default.
• W2016110231 hasConceptScore W2016110231C206276672 @default.
• W2016110231 hasConceptScore W2016110231C2524010 @default.

• next