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- W2016110538 abstract "This study evaluated the supraspinal opioid effects of 14β-(bromoacetamido)-7,8-dihydro-N(cyclopropylmethyl)-normorphinone (N-CPM-H 2 BAMO) in the mouse acetic acid-induced writhing and tail-flick assays. In the writhing test, N-CPM-H 2 BAMO produced a time- and dose-dependent antinociception after i.c.v. administration, with a 50% antinociceptive response being obtained with 0.28 (0.19–0.39) nmol when given 10 min before testing. The antinociceptive effect of N-CPM-H 2 BAMO was antagonized in a dose-dependent manner by the κ-selective opioid receptor antagonist, nor-binaltorphimine. In the mouse tail-flick assay, N-CPM-H 2 BAMO failed to produce any antinociception after i.c.v. administration. N-CPM-H 2 BAMO produced a dose-dependent antagonism of morphine-induced antinociception but not antinociception induced by the δ-opioid receptor agonist [D-Pen 2 ,D-Pen 5 ]enkephalin. Nor-binaltorphimine (0.3 nmol) at dose that completely antagonized N-CPM-H 2 BAMO-induced antinociception in the writhing assay did not prevent the antagonistic effect of N-CPM-H 2 BAMO on morphine-induced antinociception. Therefore, these data indicate that N-CPM-H 2 BAMO produces antinociception by acting at supraspinal κ-opioid receptors in the writhing assay, and also acts as a μ-opioid receptor antagonist." @default.
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- W2016110538 date "1993-08-01" @default.
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- W2016110538 title "Antinociceptive evaluation of 14β-(bromoacetamido)- 7,8-dihydro-N(cyclopropylmethyl)-normorphinone in mice" @default.
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- W2016110538 doi "https://doi.org/10.1016/0014-2999(93)90899-s" @default.
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