Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016110919> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2016110919 endingPage "175" @default.
- W2016110919 startingPage "167" @default.
- W2016110919 abstract "Since sepsis places increased demands on the host for energy and on other substrates for tissue repair and host defense, hepatic gluconeogenesis is critical for the host's adaptation to sepsis. Substrate-stimulated gluconeogenesis (i.e., gluconeogenic capacity) was assessed by the alanine load method in mannoheptulose-pretreated rats made septic by cecal ligation after laparotomy, as well as by cecal ligation and puncture after laparotomy. Fasted rats subjected to laparotomy only (sham-ligated) and fasted, nonoperated rats (controls) were investigated simultaneously. Following an overnight (−18 to 0 hr) fast, nonoperated animals converted 17.9 ± 1.5% of [14C]alanine to [14C]glucose. Continued fasting in nonoperated animals resulted in enhanced (P < 0.05) gluconeogenic capacity (6 hr = 27.2 ± 3.0%; 24 hr = 26.2 ± 1.9%; and 48 hr = 28.5 ± 2.6%) relative to Time 0. Laparotomy alone (sham ligation) delayed the fasting-induced increase (P < 0.05) in gluconeogenesis capacity (6 hr = 21.1 ± 1.2%; 24 hr = 18.5 ± 1.3%; 48 hr = 27.8 ± 1.0%) relative to Time 0. In contrast, postoperative sepsis produced a sustained depression (P < 0.05) of gluconeogenic capacity relative to nonoperated sham-ligated controls at 48 hr (cecal ligation, 18.4 ± 1.4%; and cecal ligation and puncture, 18.8 ± 1.2%). Thus, (1) fasting enhances hepatic gluconeogenic capacity; (2) surgical trauma transiently blunts the gluconeogenic response to fasting; and (3) sepsis undermines the gluconeogenic response to fasting." @default.
- W2016110919 created "2016-06-24" @default.
- W2016110919 creator A5037703738 @default.
- W2016110919 creator A5073323112 @default.
- W2016110919 date "1988-08-01" @default.
- W2016110919 modified "2023-10-18" @default.
- W2016110919 title "Effect of bacterial sepsis on gluconeogenic capacity in the rat" @default.
- W2016110919 cites W1510025470 @default.
- W2016110919 cites W1969044598 @default.
- W2016110919 cites W2021720963 @default.
- W2016110919 cites W2035433014 @default.
- W2016110919 cites W2047573371 @default.
- W2016110919 cites W2053037368 @default.
- W2016110919 cites W2060548902 @default.
- W2016110919 cites W2068846724 @default.
- W2016110919 cites W2088817871 @default.
- W2016110919 cites W2094625904 @default.
- W2016110919 cites W2105680011 @default.
- W2016110919 cites W2148833672 @default.
- W2016110919 cites W2173122722 @default.
- W2016110919 cites W2260757043 @default.
- W2016110919 cites W2409299514 @default.
- W2016110919 doi "https://doi.org/10.1016/0022-4804(88)90061-3" @default.
- W2016110919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3043107" @default.
- W2016110919 hasPublicationYear "1988" @default.
- W2016110919 type Work @default.
- W2016110919 sameAs 2016110919 @default.
- W2016110919 citedByCount "6" @default.
- W2016110919 countsByYear W20161109192012 @default.
- W2016110919 crossrefType "journal-article" @default.
- W2016110919 hasAuthorship W2016110919A5037703738 @default.
- W2016110919 hasAuthorship W2016110919A5073323112 @default.
- W2016110919 hasConcept C126322002 @default.
- W2016110919 hasConcept C134018914 @default.
- W2016110919 hasConcept C141071460 @default.
- W2016110919 hasConcept C179437574 @default.
- W2016110919 hasConcept C20904676 @default.
- W2016110919 hasConcept C2778384902 @default.
- W2016110919 hasConcept C2780778865 @default.
- W2016110919 hasConcept C62231903 @default.
- W2016110919 hasConcept C71924100 @default.
- W2016110919 hasConceptScore W2016110919C126322002 @default.
- W2016110919 hasConceptScore W2016110919C134018914 @default.
- W2016110919 hasConceptScore W2016110919C141071460 @default.
- W2016110919 hasConceptScore W2016110919C179437574 @default.
- W2016110919 hasConceptScore W2016110919C20904676 @default.
- W2016110919 hasConceptScore W2016110919C2778384902 @default.
- W2016110919 hasConceptScore W2016110919C2780778865 @default.
- W2016110919 hasConceptScore W2016110919C62231903 @default.
- W2016110919 hasConceptScore W2016110919C71924100 @default.
- W2016110919 hasIssue "2" @default.
- W2016110919 hasLocation W20161109191 @default.
- W2016110919 hasLocation W20161109192 @default.
- W2016110919 hasOpenAccess W2016110919 @default.
- W2016110919 hasPrimaryLocation W20161109191 @default.
- W2016110919 hasRelatedWork W2000010456 @default.
- W2016110919 hasRelatedWork W2019806229 @default.
- W2016110919 hasRelatedWork W2025645904 @default.
- W2016110919 hasRelatedWork W2052448937 @default.
- W2016110919 hasRelatedWork W2064940611 @default.
- W2016110919 hasRelatedWork W2091844621 @default.
- W2016110919 hasRelatedWork W2156093747 @default.
- W2016110919 hasRelatedWork W2464596983 @default.
- W2016110919 hasRelatedWork W2963017100 @default.
- W2016110919 hasRelatedWork W4246710695 @default.
- W2016110919 hasVolume "45" @default.
- W2016110919 isParatext "false" @default.
- W2016110919 isRetracted "false" @default.
- W2016110919 magId "2016110919" @default.
- W2016110919 workType "article" @default.