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• W2016112729 abstract "Abstract Background: In this study we exploit the unique genome organization of ciliates to characterize the biological function of histone modification patterns and chromatin plasticity for the processing of specific DNA sequences during a nuclear differentiation process. Ciliates are single-cell eukaryotes containing two morphologically and functionally specialized types of nuclei, the somatic macronucleus and the germline micronucleus. In the course of sexual reproduction a new macronucleus develops from a micronuclear derivative. During this process specific DNA sequences are eliminated from the genome, while sequences that will be transcribed in the mature macronucleus are retained. Results: We show by immunofluorescence microscopy, Western analyses and chromatin immunoprecipitation (ChIP) experiments that each nuclear type establishes its specific histone modification signature. Our analyses reveal that the early macronuclear anlage adopts a permissive chromatin state immediately after the fusion of two heterochromatic germline micronuclei. As macronuclear development progresses, repressive histone modifications that specify sequences to be eliminated are introduced de novo . ChIP analyses demonstrate that permissive histone modifications are associated with sequences that will be retained in the new macronucleus. Furthermore, our data support the hypothesis that a PIWI-family protein is involved in a transnuclear cross-talk and in the RNAi-dependent control of developmental chromatin reorganization. Conclusion: Based on these data we present a comprehensive analysis of the spatial and temporal pattern of histone modifications during this nuclear differentiation process. Results obtained in this study may also be relevant for our understanding of chromatin plasticity during metazoan embryogenesis." @default.
• W2016112729 created "2016-06-24" @default.
• W2016112729 creator A5006242019 @default.
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• W2016112729 creator A5069700929 @default.
• W2016112729 creator A5073152482 @default.
• W2016112729 date "2008-10-27" @default.
• W2016112729 modified "2023-10-10" @default.
• W2016112729 title "Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development" @default.
• W2016112729 cites W1493066387 @default.
• W2016112729 cites W1509466986 @default.
• W2016112729 cites W1563473290 @default.
• W2016112729 cites W1591289808 @default.
• W2016112729 cites W1603793127 @default.
• W2016112729 cites W1841489266 @default.
• W2016112729 cites W1912524364 @default.
• W2016112729 cites W1965669510 @default.
• W2016112729 cites W1973435901 @default.
• W2016112729 cites W1977733607 @default.
• W2016112729 cites W1979245454 @default.
• W2016112729 cites W1980474015 @default.
• W2016112729 cites W1981259598 @default.
• W2016112729 cites W1983569995 @default.
• W2016112729 cites W1985180051 @default.
• W2016112729 cites W1988043538 @default.
• W2016112729 cites W1993997766 @default.
• W2016112729 cites W1999284470 @default.
• W2016112729 cites W2007964754 @default.
• W2016112729 cites W2019642682 @default.
• W2016112729 cites W2020243512 @default.
• W2016112729 cites W2021767342 @default.
• W2016112729 cites W2022936129 @default.
• W2016112729 cites W2024334429 @default.
• W2016112729 cites W2024584416 @default.
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• W2016112729 cites W2032736838 @default.
• W2016112729 cites W2034949062 @default.
• W2016112729 cites W2035930185 @default.
• W2016112729 cites W2040234712 @default.
• W2016112729 cites W2041787701 @default.
• W2016112729 cites W2042633640 @default.
• W2016112729 cites W2042836025 @default.
• W2016112729 cites W2043622843 @default.
• W2016112729 cites W2044486844 @default.
• W2016112729 cites W2048843865 @default.
• W2016112729 cites W2049118388 @default.
• W2016112729 cites W2053874183 @default.
• W2016112729 cites W2053903730 @default.
• W2016112729 cites W2063982921 @default.
• W2016112729 cites W2064358462 @default.
• W2016112729 cites W2073403450 @default.
• W2016112729 cites W2077165618 @default.
• W2016112729 cites W2082442977 @default.
• W2016112729 cites W2085932408 @default.
• W2016112729 cites W2087011722 @default.
• W2016112729 cites W2092261551 @default.
• W2016112729 cites W2092368988 @default.
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• W2016112729 cites W2096083625 @default.
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• W2016112729 cites W2147017708 @default.
• W2016112729 cites W2151653586 @default.
• W2016112729 cites W2156137186 @default.
• W2016112729 cites W2166186329 @default.
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• W2016112729 doi "https://doi.org/10.1186/1756-8935-1-3" @default.
• W2016112729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2603335" @default.
• W2016112729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19014664" @default.
• W2016112729 hasPublicationYear "2008" @default.
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