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- W2016113509 abstract "Parabutoporin (PP) and opistoporin 1 (OP1) are amphipathic α-helical antimicrobial peptides that were recently isolated from scorpion venom. In assays in which single granulocyte-like HL-60 cells as well as cells in suspension were used, both peptides were able to induce a reversible Ca2+ release from intracellular stores and to increase Ca2+ influx. Both effects could be clearly differentiated for OP1, inducing Ca2+ release at lower concentrations. The Ca2+ release was pertussis toxin-sensitive indicating the involvement of G-proteins. Ca2+ release depended on the stage of differentiation of the cells with undifferentiated cells being the most sensitive. Desensitization occurred with OP1. No cross-desensitization occurred between OP1 and the bacterial chemoattractant fMLP indicating the involvement of different types of receptors. Ca2+ release by OP1 was found not to be mediated via interaction with the formyl peptide receptor-like 1. Although some of the results might favor a receptor-like interaction, the receptor involved could not be identified." @default.
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- W2016113509 date "2003-11-01" @default.
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- W2016113509 title "Antimicrobial peptides from scorpion venom induce Ca2+ signaling in HL-60 cells" @default.
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- W2016113509 doi "https://doi.org/10.1016/j.bbrc.2003.09.175" @default.
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