Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016114868> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2016114868 endingPage "181" @default.
- W2016114868 startingPage "177" @default.
- W2016114868 abstract "Type 2 diabetes is associated with altered regional blood flow and expression of nitric oxide synthase (NOS). We examined the functional role of constitutive and inducible NOS synthase (cNOS and iNOS, respectively) on regional blood flow in thiobutabarbital-anesthetized Zucker diabetic fatty (ZDF) and control rats via the radioactive microspheres technique. Blood flow was measured at baseline (1 h after surgery), after i.v. administration of 1400W (N-3-aminomethyl-benzyl-acetamidine, selective iNOS inhibitor, 3 mg/kg), and again after i.v. NG-nitro-l-arginine methyl ester (l-NAME, non-selective NOS inhibitor, 8 mg/kg). Both groups had similar baseline mean arterial pressure, cardiac output and total peripheral resistance, but the ZDF rats had lower heart rate relative to the control rats (272 versus 305 beats/min). Whereas 1400W did not alter mean arterial pressure or blood flow in either group, l-NAME markedly increased mean arterial pressure and total peripheral resistance, and reduced cardiac output, heart rate, blood flow and arterial conductance in all organs/tissues of both the control and ZDF rats. l-NAME caused greater vasoconstriction in the heart (1.5-times the constriction in control rats) and brain (1.5-times) of the ZDF rats, but less in the pancreas (0.6-times). Thus, cNOS had greater vasodilator control of the heart and brain, but less in the pancreas of the ZDF than control rats. iNOS has negligible influence on blood flow in both groups of rats." @default.
- W2016114868 created "2016-06-24" @default.
- W2016114868 creator A5018497622 @default.
- W2016114868 creator A5030140233 @default.
- W2016114868 creator A5059993792 @default.
- W2016114868 date "2008-09-01" @default.
- W2016114868 modified "2023-10-16" @default.
- W2016114868 title "Altered vasodilator role of nitric oxide synthase in the pancreas, heart and brain of rats with spontaneous type 2 diabetes" @default.
- W2016114868 cites W1979684615 @default.
- W2016114868 cites W1982630631 @default.
- W2016114868 cites W1984348170 @default.
- W2016114868 cites W1989676431 @default.
- W2016114868 cites W1990992429 @default.
- W2016114868 cites W2002832361 @default.
- W2016114868 cites W2004313143 @default.
- W2016114868 cites W2008685554 @default.
- W2016114868 cites W2011171248 @default.
- W2016114868 cites W2020541699 @default.
- W2016114868 cites W2053847900 @default.
- W2016114868 cites W2065504943 @default.
- W2016114868 cites W2073327039 @default.
- W2016114868 cites W2074771844 @default.
- W2016114868 cites W2075791946 @default.
- W2016114868 cites W2092676255 @default.
- W2016114868 cites W2095204286 @default.
- W2016114868 cites W2099366831 @default.
- W2016114868 cites W2102615617 @default.
- W2016114868 cites W2105470307 @default.
- W2016114868 cites W2127488172 @default.
- W2016114868 cites W2138561622 @default.
- W2016114868 cites W2153614451 @default.
- W2016114868 cites W2165355897 @default.
- W2016114868 cites W2166788192 @default.
- W2016114868 cites W2170131862 @default.
- W2016114868 cites W2319030457 @default.
- W2016114868 cites W2326008668 @default.
- W2016114868 cites W2413997856 @default.
- W2016114868 doi "https://doi.org/10.1016/j.ejphar.2008.06.036" @default.
- W2016114868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18585382" @default.
- W2016114868 hasPublicationYear "2008" @default.
- W2016114868 type Work @default.
- W2016114868 sameAs 2016114868 @default.
- W2016114868 citedByCount "14" @default.
- W2016114868 countsByYear W20161148682012 @default.
- W2016114868 countsByYear W20161148682013 @default.
- W2016114868 countsByYear W20161148682015 @default.
- W2016114868 countsByYear W20161148682020 @default.
- W2016114868 crossrefType "journal-article" @default.
- W2016114868 hasAuthorship W2016114868A5018497622 @default.
- W2016114868 hasAuthorship W2016114868A5030140233 @default.
- W2016114868 hasAuthorship W2016114868A5059993792 @default.
- W2016114868 hasConcept C120770815 @default.
- W2016114868 hasConcept C126322002 @default.
- W2016114868 hasConcept C134018914 @default.
- W2016114868 hasConcept C158846371 @default.
- W2016114868 hasConcept C185592680 @default.
- W2016114868 hasConcept C2776452961 @default.
- W2016114868 hasConcept C2777622882 @default.
- W2016114868 hasConcept C2777953023 @default.
- W2016114868 hasConcept C519581460 @default.
- W2016114868 hasConcept C555293320 @default.
- W2016114868 hasConcept C58245268 @default.
- W2016114868 hasConcept C71924100 @default.
- W2016114868 hasConcept C84393581 @default.
- W2016114868 hasConceptScore W2016114868C120770815 @default.
- W2016114868 hasConceptScore W2016114868C126322002 @default.
- W2016114868 hasConceptScore W2016114868C134018914 @default.
- W2016114868 hasConceptScore W2016114868C158846371 @default.
- W2016114868 hasConceptScore W2016114868C185592680 @default.
- W2016114868 hasConceptScore W2016114868C2776452961 @default.
- W2016114868 hasConceptScore W2016114868C2777622882 @default.
- W2016114868 hasConceptScore W2016114868C2777953023 @default.
- W2016114868 hasConceptScore W2016114868C519581460 @default.
- W2016114868 hasConceptScore W2016114868C555293320 @default.
- W2016114868 hasConceptScore W2016114868C58245268 @default.
- W2016114868 hasConceptScore W2016114868C71924100 @default.
- W2016114868 hasConceptScore W2016114868C84393581 @default.
- W2016114868 hasIssue "1-3" @default.
- W2016114868 hasLocation W20161148681 @default.
- W2016114868 hasLocation W20161148682 @default.
- W2016114868 hasOpenAccess W2016114868 @default.
- W2016114868 hasPrimaryLocation W20161148681 @default.
- W2016114868 hasRelatedWork W2008087125 @default.
- W2016114868 hasRelatedWork W2054818626 @default.
- W2016114868 hasRelatedWork W2056841269 @default.
- W2016114868 hasRelatedWork W2089295326 @default.
- W2016114868 hasRelatedWork W2093911704 @default.
- W2016114868 hasRelatedWork W2163475302 @default.
- W2016114868 hasRelatedWork W2385068922 @default.
- W2016114868 hasRelatedWork W2441472761 @default.
- W2016114868 hasRelatedWork W2748952813 @default.
- W2016114868 hasRelatedWork W2948290726 @default.
- W2016114868 hasVolume "591" @default.
- W2016114868 isParatext "false" @default.
- W2016114868 isRetracted "false" @default.
- W2016114868 magId "2016114868" @default.
- W2016114868 workType "article" @default.