Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016114917> ?p ?o ?g. }
- W2016114917 endingPage "328" @default.
- W2016114917 startingPage "321" @default.
- W2016114917 abstract "Estrogen receptor α (ERα) has been reported to play a critical role in promoting the growth of breast tumor cells. In the present study, we explored the effect of Huaier extract on estrogen receptor α signaling in breast cancer cell lines. Our data demonstrated that Huaier extract effectively inhibited the proliferation of the MCF-7, T47D and ZR-75-1 human breast cancer cell lines. For the mechanism analysis, we demonstrated that Huaier extract significantly reduced the mRNA and protein levels of ERα in all three ERα-positive cell lines. The downregulation of ERα protein levels was correlated with activation of the proteasomes. We demonstrated that Huaier extract markedly decreased the expression of both ERα and its downstream genes, inhibited the estrogen-stimulated proliferation and reversed the estrogen-induced activation of the nuclear factor κB (NFκB) pathway. Our study provides evidence that Huaier extract is a novel estrogen receptor modulator and is a promising drug for the prevention and treatment of ERα-positive human breast cancers." @default.
- W2016114917 created "2016-06-24" @default.
- W2016114917 creator A5012872535 @default.
- W2016114917 creator A5016935464 @default.
- W2016114917 creator A5036936468 @default.
- W2016114917 creator A5039782279 @default.
- W2016114917 creator A5066028215 @default.
- W2016114917 creator A5078540705 @default.
- W2016114917 date "2013-05-20" @default.
- W2016114917 modified "2023-10-16" @default.
- W2016114917 title "Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling" @default.
- W2016114917 cites W1508838109 @default.
- W2016114917 cites W1529944274 @default.
- W2016114917 cites W1549100704 @default.
- W2016114917 cites W1955010715 @default.
- W2016114917 cites W1966475217 @default.
- W2016114917 cites W1969969891 @default.
- W2016114917 cites W1975740303 @default.
- W2016114917 cites W1981436766 @default.
- W2016114917 cites W1993208922 @default.
- W2016114917 cites W2010659438 @default.
- W2016114917 cites W2013809140 @default.
- W2016114917 cites W2016214889 @default.
- W2016114917 cites W2020038984 @default.
- W2016114917 cites W2023653196 @default.
- W2016114917 cites W2025002326 @default.
- W2016114917 cites W2040882319 @default.
- W2016114917 cites W2045389096 @default.
- W2016114917 cites W2068890508 @default.
- W2016114917 cites W2081491080 @default.
- W2016114917 cites W2081876561 @default.
- W2016114917 cites W2082289906 @default.
- W2016114917 cites W2093254833 @default.
- W2016114917 cites W2093350076 @default.
- W2016114917 cites W2095546315 @default.
- W2016114917 cites W2101466921 @default.
- W2016114917 cites W2112444654 @default.
- W2016114917 cites W2125077061 @default.
- W2016114917 cites W2137355132 @default.
- W2016114917 cites W2141647078 @default.
- W2016114917 cites W2145635871 @default.
- W2016114917 cites W2146669857 @default.
- W2016114917 cites W2147673480 @default.
- W2016114917 cites W2152821238 @default.
- W2016114917 cites W2155284234 @default.
- W2016114917 cites W2167107784 @default.
- W2016114917 cites W2167956824 @default.
- W2016114917 doi "https://doi.org/10.3892/ijo.2013.1947" @default.
- W2016114917 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23686317" @default.
- W2016114917 hasPublicationYear "2013" @default.
- W2016114917 type Work @default.
- W2016114917 sameAs 2016114917 @default.
- W2016114917 citedByCount "26" @default.
- W2016114917 countsByYear W20161149172014 @default.
- W2016114917 countsByYear W20161149172015 @default.
- W2016114917 countsByYear W20161149172016 @default.
- W2016114917 countsByYear W20161149172017 @default.
- W2016114917 countsByYear W20161149172019 @default.
- W2016114917 countsByYear W20161149172020 @default.
- W2016114917 countsByYear W20161149172021 @default.
- W2016114917 crossrefType "journal-article" @default.
- W2016114917 hasAuthorship W2016114917A5012872535 @default.
- W2016114917 hasAuthorship W2016114917A5016935464 @default.
- W2016114917 hasAuthorship W2016114917A5036936468 @default.
- W2016114917 hasAuthorship W2016114917A5039782279 @default.
- W2016114917 hasAuthorship W2016114917A5066028215 @default.
- W2016114917 hasAuthorship W2016114917A5078540705 @default.
- W2016114917 hasBestOaLocation W20161149171 @default.
- W2016114917 hasConcept C104317684 @default.
- W2016114917 hasConcept C121608353 @default.
- W2016114917 hasConcept C126322002 @default.
- W2016114917 hasConcept C127561419 @default.
- W2016114917 hasConcept C134018914 @default.
- W2016114917 hasConcept C170493617 @default.
- W2016114917 hasConcept C172313692 @default.
- W2016114917 hasConcept C2777164284 @default.
- W2016114917 hasConcept C2781018059 @default.
- W2016114917 hasConcept C29537977 @default.
- W2016114917 hasConcept C502942594 @default.
- W2016114917 hasConcept C530470458 @default.
- W2016114917 hasConcept C55493867 @default.
- W2016114917 hasConcept C62112901 @default.
- W2016114917 hasConcept C62478195 @default.
- W2016114917 hasConcept C67082663 @default.
- W2016114917 hasConcept C71924100 @default.
- W2016114917 hasConcept C84606932 @default.
- W2016114917 hasConcept C86803240 @default.
- W2016114917 hasConcept C95444343 @default.
- W2016114917 hasConcept C96307122 @default.
- W2016114917 hasConceptScore W2016114917C104317684 @default.
- W2016114917 hasConceptScore W2016114917C121608353 @default.
- W2016114917 hasConceptScore W2016114917C126322002 @default.
- W2016114917 hasConceptScore W2016114917C127561419 @default.
- W2016114917 hasConceptScore W2016114917C134018914 @default.
- W2016114917 hasConceptScore W2016114917C170493617 @default.
- W2016114917 hasConceptScore W2016114917C172313692 @default.
- W2016114917 hasConceptScore W2016114917C2777164284 @default.
- W2016114917 hasConceptScore W2016114917C2781018059 @default.