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- W2016116417 abstract "Background: Liquid microsampling can realize ethical benefits through reduced animal usage. It inherently deals with a minute amount of sample; for example, <30 µl of plasma, which is generally insufficient for multiple analyses. Results: We report accurate weighing and dilution-assisted plasma microsampling (AWADA-PM) that substantially increases sample sizes (e.g., by tenfold). Plasma samples are harvested from blood samples (∼70 µl) in capillaries. The plasma samples are weighed with a calibrated balance. The weights are converted to volumes using a standard plasma density of 1.025 g/cm 3 . Diluent is added with a calibrated pipette to the harvested plasma to achieve a tenfold dilution. Conclusion: The proof-of-concept for AWADA-PM was successfully demonstrated for the quantitation of acetaminophen in rat plasma (K 2 EDTA) using liquid chromatography–tandem mass spectrometry employing water and blank rat plasma as diluents. The results clearly demonstrate that the AWADA-PM strategy is an easy-to-implement and reliable microsampling technology that has potential for full regulatory compliance." @default.
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- W2016116417 date "2014-03-01" @default.
- W2016116417 modified "2023-09-24" @default.
- W2016116417 title "Accurate weighing and dilution-assisted plasma microsampling (AWADA-PM): an easy-to-implement and rugged strategy" @default.
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- W2016116417 doi "https://doi.org/10.4155/bio.14.22" @default.
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