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- W2016116660 abstract "The effects of chronic zinc supplementation to Wistar rats at two doses (elemental) 50mg/g of diet (group-I) and 400mg/g of diet (group-II) on (i) lipid peroxidation status, superoxide dismutase activity, iron, and ceruloplasmin levels and (ii) circadian oscillations of glucose, total protein, alkalinephosphatase activity and thiobarbituric acid reactive substances were investigated. Iron in tissues (liver & kidney), ceruloplasmin, thiobarbituric acid reactive substances in plasma and tissues were found to be decreased in zinc supplemented groups. Superoxide dismutase activity in liver of group-I animals was increased but slightly decreased in group-II animals. Zinc might competitively inhibit the iron uptake by ferritin thereby reducing their levels. The increased activity of superoxide dismutase (in group I) might be due to induction/stabilisation of the enzyme by zinc. Induction of metallothionein and modulation of iron and copper levels during zinc supplementation might lead to low levels of lipid peroxidation. The peak time of circadian oscillation of total protein was delayed by three hours (during zinc supplementation). This might be due to altered positive or negative balance between synthesis and degradation of protein during zinc supplementation." @default.
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- W2016116660 date "2000-03-01" @default.
- W2016116660 modified "2023-09-26" @default.
- W2016116660 title "Influence of chronic zinc supplementation on biochemical variables and circadian rhythms in Wistar rats" @default.
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- W2016116660 doi "https://doi.org/10.1016/s0271-5317(00)00134-2" @default.
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