FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016116714> ?p ?o ?g. }

• W2016116714 endingPage "198" @default.
• W2016116714 startingPage "191" @default.
• W2016116714 abstract "Accumulating genetic and biochemical evidences support a role for the SWI/SNF chromatin-remodeling complex in cancer development and multiple core subunits of these complexes have been found to function as tumor suppressor genes. The core SWI/SNF subunit BAF57 mediates direct interactions with estrogen and androgen receptors (ER and AR) regulating their transcriptional activity. BAF57 gene maps to chromosome band 17 q21 in close proximity to the BRCA1 gene. This locus has been associated with frequent loss of heterozygosity (LOH) and allelic imbalance in breast cancers; however, BRCA1 mutations are rare events in sporadic breast cancer with LOH in the region, suggesting that another tumor suppressor gene resides in this area. All these reasons prompted us to screen for mutations in the BAF57 gene using a panel of the most commonly used human breast cancer cell lines. All cell lines analysed contain wild-type copies of BAF57 gene with the only exception of the breast ductal carcinoma cell line BT549. Sequencing of genomic DNA and cDNA generated from BT549 mRNA demonstrated the presence of a CA dinucleotide insertion in exon 5 of BAF57. The absence of wild-type BAF57 alleles indicates that this is a biallelic inactivating mutation that causes a frameshift and as a consequence a premature stop codon leading to a truncated BAF57 protein. A functional characterisation of the truncated BAF57 showed that it has lost the ability to bind to ER but still binds to the nuclear receptor coactivator SRC1e. Furthermore, we observed that the expression of the truncated BAF57 increased the ability of SRC1e to potentiate transcriptional activation by ERα, suggesting that mutations in BAF57 could contribute to the oncogenic transformation in breast cancer cells." @default.
• W2016116714 created "2016-06-24" @default.
• W2016116714 creator A5022237626 @default.
• W2016116714 creator A5038996505 @default.
• W2016116714 creator A5045167647 @default.
• W2016116714 creator A5081025221 @default.
• W2016116714 creator A5083722213 @default.
• W2016116714 date "2006-03-15" @default.
• W2016116714 modified "2023-10-03" @default.
• W2016116714 title "Identification of BAF57 mutations in human breast cancer cell lines" @default.
• W2016116714 cites W1559451312 @default.
• W2016116714 cites W1760824447 @default.
• W2016116714 cites W1966538470 @default.
• W2016116714 cites W1974220331 @default.
• W2016116714 cites W1979256255 @default.
• W2016116714 cites W1990529844 @default.
• W2016116714 cites W2005941837 @default.
• W2016116714 cites W2012523195 @default.
• W2016116714 cites W2017203551 @default.
• W2016116714 cites W2025721764 @default.
• W2016116714 cites W2036546668 @default.
• W2016116714 cites W2049953612 @default.
• W2016116714 cites W2052137719 @default.
• W2016116714 cites W2054188881 @default.
• W2016116714 cites W2065346432 @default.
• W2016116714 cites W2072139657 @default.
• W2016116714 cites W2077858999 @default.
• W2016116714 cites W2091961739 @default.
• W2016116714 cites W2103991023 @default.
• W2016116714 cites W2121092400 @default.
• W2016116714 cites W2146689455 @default.
• W2016116714 cites W2169698993 @default.
• W2016116714 cites W2172256092 @default.
• W2016116714 cites W2340200299 @default.
• W2016116714 cites W4240013922 @default.
• W2016116714 cites W4385970158 @default.
• W2016116714 doi "https://doi.org/10.1007/s10549-005-9149-9" @default.
• W2016116714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16538531" @default.
• W2016116714 hasPublicationYear "2006" @default.
• W2016116714 type Work @default.
• W2016116714 sameAs 2016116714 @default.
• W2016116714 citedByCount "26" @default.
• W2016116714 countsByYear W20161167142012 @default.
• W2016116714 countsByYear W20161167142013 @default.
• W2016116714 countsByYear W20161167142014 @default.
• W2016116714 countsByYear W20161167142015 @default.
• W2016116714 countsByYear W20161167142016 @default.
• W2016116714 countsByYear W20161167142019 @default.
• W2016116714 countsByYear W20161167142022 @default.
• W2016116714 crossrefType "journal-article" @default.
• W2016116714 hasAuthorship W2016116714A5022237626 @default.
• W2016116714 hasAuthorship W2016116714A5038996505 @default.
• W2016116714 hasAuthorship W2016116714A5045167647 @default.
• W2016116714 hasAuthorship W2016116714A5081025221 @default.
• W2016116714 hasAuthorship W2016116714A5083722213 @default.
• W2016116714 hasBestOaLocation W20161167142 @default.
• W2016116714 hasConcept C104317684 @default.
• W2016116714 hasConcept C121608353 @default.
• W2016116714 hasConcept C143589142 @default.
• W2016116714 hasConcept C153911025 @default.
• W2016116714 hasConcept C166941617 @default.
• W2016116714 hasConcept C167227067 @default.
• W2016116714 hasConcept C180754005 @default.
• W2016116714 hasConcept C2778264664 @default.
• W2016116714 hasConcept C29906990 @default.
• W2016116714 hasConcept C36823959 @default.
• W2016116714 hasConcept C41091548 @default.
• W2016116714 hasConcept C502942594 @default.
• W2016116714 hasConcept C530470458 @default.
• W2016116714 hasConcept C54355233 @default.
• W2016116714 hasConcept C555283112 @default.
• W2016116714 hasConcept C77445288 @default.
• W2016116714 hasConcept C86339819 @default.
• W2016116714 hasConcept C86803240 @default.
• W2016116714 hasConceptScore W2016116714C104317684 @default.
• W2016116714 hasConceptScore W2016116714C121608353 @default.
• W2016116714 hasConceptScore W2016116714C143589142 @default.
• W2016116714 hasConceptScore W2016116714C153911025 @default.
• W2016116714 hasConceptScore W2016116714C166941617 @default.
• W2016116714 hasConceptScore W2016116714C167227067 @default.
• W2016116714 hasConceptScore W2016116714C180754005 @default.
• W2016116714 hasConceptScore W2016116714C2778264664 @default.
• W2016116714 hasConceptScore W2016116714C29906990 @default.
• W2016116714 hasConceptScore W2016116714C36823959 @default.
• W2016116714 hasConceptScore W2016116714C41091548 @default.
• W2016116714 hasConceptScore W2016116714C502942594 @default.
• W2016116714 hasConceptScore W2016116714C530470458 @default.
• W2016116714 hasConceptScore W2016116714C54355233 @default.
• W2016116714 hasConceptScore W2016116714C555283112 @default.
• W2016116714 hasConceptScore W2016116714C77445288 @default.
• W2016116714 hasConceptScore W2016116714C86339819 @default.
• W2016116714 hasConceptScore W2016116714C86803240 @default.
• W2016116714 hasIssue "2" @default.
• W2016116714 hasLocation W20161167141 @default.
• W2016116714 hasLocation W20161167142 @default.
• W2016116714 hasLocation W20161167143 @default.
• W2016116714 hasOpenAccess W2016116714 @default.
• W2016116714 hasPrimaryLocation W20161167141 @default.

• next