Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016117582> ?p ?o ?g. }
- W2016117582 endingPage "C961" @default.
- W2016117582 startingPage "C953" @default.
- W2016117582 abstract "Altered mucosal integrity and increased cytokine production, including tumor necrosis factor (TNF), are the hallmarks of inflammatory bowel disease (IBD). In this study, we addressed the role of TNF receptors (TNFR) on intestinal epithelial cell migration in an in vitro wound closure model. With mouse TNFR1 or TNFR2 knockout intestinal epithelial cells, gene transfection, and pharmacological inhibitors, we show a concentration-dependent receptor-mediated regulation of intestinal cell migration by TNF. A physiological TNF level (1 ng/ml) enhances migration through TNFR2, whereas a pathological level (100 ng/ml) inhibits wound closure through TNFR1. Increased rate of wound closure by TNFR2 or inhibition by TNFR1 cannot be explained by either increased proliferation or apoptosis, respectively. Furthermore, inhibiting Src tyrosine kinase decreases TNF-induced focal adhesion kinase (FAK) tyrosine phosphorylation and cellular migration. We therefore conclude that TNFR2 activates a novel Src-regulated pathway involving FAK tyrosine phosphorylation that enhances migration of intestinal epithelial cells." @default.
- W2016117582 created "2016-06-24" @default.
- W2016117582 creator A5003460722 @default.
- W2016117582 creator A5014815275 @default.
- W2016117582 creator A5035631181 @default.
- W2016117582 creator A5045107498 @default.
- W2016117582 creator A5049653299 @default.
- W2016117582 creator A5053944825 @default.
- W2016117582 creator A5065834588 @default.
- W2016117582 creator A5072089114 @default.
- W2016117582 date "2003-04-01" @default.
- W2016117582 modified "2023-10-01" @default.
- W2016117582 title "Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms" @default.
- W2016117582 cites W1521881285 @default.
- W2016117582 cites W1561993052 @default.
- W2016117582 cites W1581093018 @default.
- W2016117582 cites W1604164531 @default.
- W2016117582 cites W1845277443 @default.
- W2016117582 cites W1949688967 @default.
- W2016117582 cites W1974424681 @default.
- W2016117582 cites W1984113136 @default.
- W2016117582 cites W1989997867 @default.
- W2016117582 cites W1995457093 @default.
- W2016117582 cites W1996460292 @default.
- W2016117582 cites W1997677936 @default.
- W2016117582 cites W2002209097 @default.
- W2016117582 cites W2004751481 @default.
- W2016117582 cites W2006699412 @default.
- W2016117582 cites W2006892275 @default.
- W2016117582 cites W2007349364 @default.
- W2016117582 cites W2014257728 @default.
- W2016117582 cites W2017086844 @default.
- W2016117582 cites W2020257412 @default.
- W2016117582 cites W2027586189 @default.
- W2016117582 cites W2028691987 @default.
- W2016117582 cites W2036500213 @default.
- W2016117582 cites W2044105551 @default.
- W2016117582 cites W2057264565 @default.
- W2016117582 cites W2067437104 @default.
- W2016117582 cites W2068461173 @default.
- W2016117582 cites W2068540074 @default.
- W2016117582 cites W2072380594 @default.
- W2016117582 cites W2083458143 @default.
- W2016117582 cites W2088657493 @default.
- W2016117582 cites W2105356859 @default.
- W2016117582 cites W2114673368 @default.
- W2016117582 cites W2117734033 @default.
- W2016117582 cites W2118995428 @default.
- W2016117582 cites W2127298694 @default.
- W2016117582 cites W2131192078 @default.
- W2016117582 cites W2138642580 @default.
- W2016117582 cites W2138787836 @default.
- W2016117582 cites W2139902700 @default.
- W2016117582 cites W2141679700 @default.
- W2016117582 cites W2148422863 @default.
- W2016117582 cites W2154708873 @default.
- W2016117582 cites W2160839395 @default.
- W2016117582 cites W2162465275 @default.
- W2016117582 cites W2267678971 @default.
- W2016117582 cites W2319839183 @default.
- W2016117582 cites W2321453230 @default.
- W2016117582 cites W2414162839 @default.
- W2016117582 cites W346385106 @default.
- W2016117582 cites W4237618369 @default.
- W2016117582 cites W4241061598 @default.
- W2016117582 doi "https://doi.org/10.1152/ajpcell.00309.2002" @default.
- W2016117582 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12466150" @default.
- W2016117582 hasPublicationYear "2003" @default.
- W2016117582 type Work @default.
- W2016117582 sameAs 2016117582 @default.
- W2016117582 citedByCount "110" @default.
- W2016117582 countsByYear W20161175822012 @default.
- W2016117582 countsByYear W20161175822013 @default.
- W2016117582 countsByYear W20161175822014 @default.
- W2016117582 countsByYear W20161175822015 @default.
- W2016117582 countsByYear W20161175822016 @default.
- W2016117582 countsByYear W20161175822017 @default.
- W2016117582 countsByYear W20161175822018 @default.
- W2016117582 countsByYear W20161175822019 @default.
- W2016117582 countsByYear W20161175822020 @default.
- W2016117582 countsByYear W20161175822021 @default.
- W2016117582 countsByYear W20161175822022 @default.
- W2016117582 countsByYear W20161175822023 @default.
- W2016117582 crossrefType "journal-article" @default.
- W2016117582 hasAuthorship W2016117582A5003460722 @default.
- W2016117582 hasAuthorship W2016117582A5014815275 @default.
- W2016117582 hasAuthorship W2016117582A5035631181 @default.
- W2016117582 hasAuthorship W2016117582A5045107498 @default.
- W2016117582 hasAuthorship W2016117582A5049653299 @default.
- W2016117582 hasAuthorship W2016117582A5053944825 @default.
- W2016117582 hasAuthorship W2016117582A5065834588 @default.
- W2016117582 hasAuthorship W2016117582A5072089114 @default.
- W2016117582 hasConcept C108636557 @default.
- W2016117582 hasConcept C11960822 @default.
- W2016117582 hasConcept C126322002 @default.
- W2016117582 hasConcept C137738243 @default.
- W2016117582 hasConcept C1491633281 @default.
- W2016117582 hasConcept C151166631 @default.