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- W2016117786 abstract "Nous décrivons un cas d'agranulocytose grave, avec mise en jeu du pronostic vital, chez un patient atteint de tétraplégie post-traumatique. Des complications intercurrentes avaient nécessité de nombreux médicaments. Après un mois d'hospitalisation, les polynucléaires neutrophiles s'abaissaient pendant dix jours jusqu'à un nadir de 70·mm−3; cette agranulocytose était associée à un syndrome infectieux. Le myélogramme montrait une hypoplasie granuleuse sévère avec absence totale de différenciation terminale. Un traitement par facteur de croissance granulocytaire a été nécessaire. Après enquête, la carbamazépine (Tégrétol®) a été retenue comme cause de cet accident. D'autres médicaments, essentiellement les antibiotiques, ont pu jouer un rôle.Severe agranulocytosis from carbamazepine. We describe a case of severe drug-induced agranulocytosis, with the risk of a lethal outcome in a patient with a posttraumatic tetraplegia. Intercurrent complications required numerous medicaments. One month after admission, the neutrophil count decreased for ten days until a nadir of 70·mm−3, associated with an infectious syndrome. The bone marrow biopsy showed a severe granulocyte hypoplasia with absence of final differentiation. Administration of ienograstime (granulocyte stimulating factor) was efficient. In this patient, carbamazepine was the most probable causal factor for agranulocytosis. However, other medicaments, mainly antibiotics, could have been contributing factors." @default.
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- W2016117786 title "Ticlopidine (Ticlid®) et aplasie médullaire sévère" @default.
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- W2016117786 doi "https://doi.org/10.1016/s0248-8663(97)80852-1" @default.
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