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- W2016120721 abstract "TO investigate whether the dorsal periaqueductal grey (DPAG) might be involved in the anxiogenic effect of intracerebroventricular (i.c.v.) administered corticotropin-releasing hormone (CRH), rats (n = 6–13) received microinjections into the DPAG of CRH (1 or 2 μg) or saline and were tested on the elevated plus maze. The drug caused a dose-dependent decrease in plus maze exploration (percentage of entries into open arms: saline 31.9 ± 8.6, CRH 1 μg 19.2 ± 4.0, CRH 2 μg 6.9 ± 3.7; p < 0.01, ANOVA). In a second experiment the anxiogenic effect of intra-DPAG CRH (2 μg) was prevented by previous microinjection of alpha-helical-CRH9-41 (0.5 μg), a CRH antagonist (percentage of entries into open arms: saline + CRH 20.3 ± 3.7, alpha-helical-CRH941 + CRH 45.7 ± 1.6). These results suggest that the DPAG may be a site of the anxiogenic effect of i.c.v. injected CRH." @default.
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- W2016120721 title "Anxiogenic effect of corticotropin-releasing hormone in the dorsal periaqueductal grey" @default.
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- W2016120721 doi "https://doi.org/10.1097/00001756-199711100-00036" @default.
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