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- W2016120736 abstract "It is suggested that in Latin America the greatest mortality in infancy beyond the neonatal period occurs mostly in malnourished infants of the marasmic type (marasmus and underweight infants) under 12 months but mainly under 6 months. Therefore the immune capacity of 47 marasmic 1-12 month old infants with weights below 75% of Brazilian standards and of 12 well-nourished healthy controls was studied in Sao Paulo Brazil. This was done by measuring the absolute and relative T and B lymphocyte subpopulations the blastogenic response to phytohemagglutini (PHA) expressed as stimulation index (SI) and the delayed hypersensitivity skin test with PHA. 8 (17%) of the malnourished infants died and the results were evaluated with respect to ultimate outcome. In addition a discriminant analysis was retrospectively applied to the immunological data of the 2 groups of malnourished infants. Both groups of malnourished infants presented significantly lower values than the control group for all measurements although not very evident for B lymphocytes. The immunodepression was more intense for the infants who died than for those who survived as shown by significantly lower values for the SI the skin test and by the discriminant analysis. The discriminant analysis led to a linear predicitve model which accurately classified 85% of the survivors and 100% of those who died. It was concluded that immunological parameters may be useful to select prospectively those infants who need a different therapeutic approach because of their high risk of mortality." @default.
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- W2016120736 title "Immunological Assessment and its Predictive Role in Malnourished Infants with Diarrhoea and/or Systemic Infections" @default.
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- W2016120736 doi "https://doi.org/10.1093/tropej/34.2.52" @default.
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