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• W2016121370 abstract "Abstract β-Casomorphins are a family of opioid peptides originally isolated from β-casein. In view of a possible physiological significance of these milk-derived compounds, the effects of bovine β-casomorphin-5 (β-CM-5), β-casomorphin-4 (β-CM-4) and D-Ala2-β-casomorphin-4-NH2 (D-Ala2-β-CM-4-NH2) have been investigated on the peristaltic reflex in the guinea-pig isolated colon and compared with morphine. β-CM-5 and D-Ala2-β-CM-4-NH2 each dose-dependently inhibited the velocity of propulsion of an intraluminal bolus; β-CM-4 was ineffective. IC50 values were 0·30, 5·21 and 0·29 μfor morphine, β-CM-5 and D-Ala2-β-CM-4-NH2, respectively. The potency ratios vs morphine were 0·06 and 0·96 for β-CM-5 and D-Ala2-β-CM-4-NH2, respectively. Blockade of the peristaltic reflex by β-CM-5 or D-Ala2-β-CM-4-NH2 was reversed by the opioid antagonist naloxone. D-Ala2-β-CM-4-NH2 also dose-dependently inhibited resting acetylcholine output (IC50 = 5·69 μM; potency ratio vs morphine: 0·63). In conclusion, certain β-casomorphins inhibit intestinal propulsion and cholinergic neurotransmission in the guinea-pig colon, probably by acting at opioid receptors." @default.
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• W2016121370 date "1989-05-01" @default.
• W2016121370 modified "2023-10-14" @default.
• W2016121370 title "Effect of β-Casomorphins on Intestinal Propulsion in the Guinea-pig Colon" @default.
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• W2016121370 doi "https://doi.org/10.1111/j.2042-7158.1989.tb06461.x" @default.
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