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- W2016122025 abstract "Abstract A new principle of fixation was developed for the histochemical demonstration of neuronal glycogen in the rabbit because of the poor results obtained after routine perfusion with saline and Bouin's solution. Accordingly, all perfusates are mixed with 0.01 m iodoacetic acid, and as soon as possible after narcosis and exposure of the heart, epinephrine is injected into the left ventricle; 30 s later the heart is incised for perfusion with aqueous 0.9% NaCl solution (30 s), followed by perfusion with Bouin's solution (6 to 8 min), and 15 to 180 min thereafter by perfusion with 100% ethanol (60 min). Then, the brain is removed and dehydrated by immersion in the same alcohol solution and embedded in paraffin within 24 h after the perfusion. The dimedone-PAS-stained neuronal glycogen, which is unstained after saliva treatment, is regarded as being better preserved because (i) it is demonstrable in the perikarya of cortical neurons and Purkinje cells, (ii) it occurs throughout the perikarya in the deeply situated Purkinje cells, and (iii) it is more intensely stained in motor neurons than with previous techniques. The beneficial effect of the iodoacetic acid on preservation of neuronal glycogen depends on the vasoconstricting action of epinephrine on the peripheral vasculature so that flow of perfusates is directed to the brain exclusively. In superficially situated Purkinje cells, glycogen, because of the action of the infiltrating alcohol, is dispersed to one side of the perikarya and aggregated in the proximal parts of axons, but is unchanged in dendrons. The differential effect of alcohol on glycogen at the three cellular levels and the observation that glycogen is reduced in astrocytes but not in neurons after the intracardial injection of epinephrine suggest that factors controlling the storage of glycogen are variable." @default.
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- W2016122025 title "Improved preservation of neuronal glycogen by fixation with iodoacetic acid-containing solutions" @default.
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- W2016122025 doi "https://doi.org/10.1016/0014-4886(81)90234-x" @default.
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