FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2016124523> ?p ?o ?g. }

• W2016124523 endingPage "34" @default.
• W2016124523 startingPage "27" @default.
• W2016124523 abstract "Clocinnamox is a long-lasting, nonequilibrium, mu-opioid receptor antagonist in mice and monkeys. The present studies examined the in vivo and ex vivo effects of clocinnamox in rats. Under control conditions, morphine dose-dependently increased tail-withdrawal latencies from 50 degrees C water, with a mean ED50 of 7.3 +/- 1.1 mg/kg. Clocinnamox antagonized the antinociceptive effects of morphine. 1.0 mg/kg clocinnamox displaced the morphine dose-response curve 4-fold to the right of the control curve and 10 mg/kg clocinnamox eliminated morphine's antinociceptive effects at doses up to 1000 mg/kg for at least seven days. There was a gradual recovery of the antinociceptive response to morphine; however, the morphine dose-response curve did not return to its original position by five weeks after 10 mg/kg clocinnamox. Whole brain membranes were prepared from separate groups of rats for determination of binding parameters of [3H][D-Ala2, N-Me-Phe4,Gly5-ol]-enkephalin (DAMGO). Clocinnamox dose-dependently decreased [3H]DAMGO binding ex vivo and the decreased binding was a result of changes in Bmax. The control Bmax for [3H]DAMGO was 234 +/- 8 fmol/mg protein; in membranes prepared from rats pretreated with 10 mg/kg clocinnamox, the Bmax value for [3H]DAMGO was 54 +/- 2 fmol/mg protein. The Bmax values for [3H]DAMGO binding after an injection of 10 mg/kg clocinnamox returned towards control values gradually, four weeks after clocinnamox the Bmax was 178 +/- 10 fmol/mg protein. These results suggest that clocinnamox is a long-lasting, nonequilibrium mu-opioid receptor antagonist in rats." @default.
• W2016124523 created "2016-06-24" @default.
• W2016124523 creator A5010424086 @default.
• W2016124523 creator A5053275074 @default.
• W2016124523 date "1997-10-01" @default.
• W2016124523 modified "2023-10-18" @default.
• W2016124523 title "Clocinnamox dose-dependently antagonizes morphine-analgesia and []DAMGO binding in rats" @default.
• W2016124523 cites W1900312436 @default.
• W2016124523 cites W1940148001 @default.
• W2016124523 cites W1964544573 @default.
• W2016124523 cites W1969909813 @default.
• W2016124523 cites W2017469000 @default.
• W2016124523 cites W2038991827 @default.
• W2016124523 cites W2040825227 @default.
• W2016124523 cites W2043470782 @default.
• W2016124523 cites W2045683430 @default.
• W2016124523 cites W2063385111 @default.
• W2016124523 cites W2084886396 @default.
• W2016124523 cites W2097635080 @default.
• W2016124523 cites W2128635872 @default.
• W2016124523 cites W2133910123 @default.
• W2016124523 cites W2140257707 @default.
• W2016124523 cites W2145346872 @default.
• W2016124523 cites W2215370060 @default.
• W2016124523 cites W2257906161 @default.
• W2016124523 cites W2261356267 @default.
• W2016124523 cites W2264583664 @default.
• W2016124523 cites W2288722943 @default.
• W2016124523 cites W2295765304 @default.
• W2016124523 cites W2395138660 @default.
• W2016124523 cites W2415850617 @default.
• W2016124523 cites W2468828877 @default.
• W2016124523 doi "https://doi.org/10.1016/s0014-2999(97)01296-x" @default.
• W2016124523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9389377" @default.
• W2016124523 hasPublicationYear "1997" @default.
• W2016124523 type Work @default.
• W2016124523 sameAs 2016124523 @default.
• W2016124523 citedByCount "19" @default.
• W2016124523 countsByYear W20161245232012 @default.
• W2016124523 countsByYear W20161245232013 @default.
• W2016124523 countsByYear W20161245232016 @default.
• W2016124523 countsByYear W20161245232020 @default.
• W2016124523 crossrefType "journal-article" @default.
• W2016124523 hasAuthorship W2016124523A5010424086 @default.
• W2016124523 hasAuthorship W2016124523A5053275074 @default.
• W2016124523 hasConcept C126322002 @default.
• W2016124523 hasConcept C134018914 @default.
• W2016124523 hasConcept C14397066 @default.
• W2016124523 hasConcept C150903083 @default.
• W2016124523 hasConcept C15490471 @default.
• W2016124523 hasConcept C170493617 @default.
• W2016124523 hasConcept C185592680 @default.
• W2016124523 hasConcept C207001950 @default.
• W2016124523 hasConcept C2776401185 @default.
• W2016124523 hasConcept C2776885963 @default.
• W2016124523 hasConcept C2777389121 @default.
• W2016124523 hasConcept C2777803847 @default.
• W2016124523 hasConcept C2781063702 @default.
• W2016124523 hasConcept C42533223 @default.
• W2016124523 hasConcept C55493867 @default.
• W2016124523 hasConcept C71924100 @default.
• W2016124523 hasConcept C86803240 @default.
• W2016124523 hasConcept C98274493 @default.
• W2016124523 hasConceptScore W2016124523C126322002 @default.
• W2016124523 hasConceptScore W2016124523C134018914 @default.
• W2016124523 hasConceptScore W2016124523C14397066 @default.
• W2016124523 hasConceptScore W2016124523C150903083 @default.
• W2016124523 hasConceptScore W2016124523C15490471 @default.
• W2016124523 hasConceptScore W2016124523C170493617 @default.
• W2016124523 hasConceptScore W2016124523C185592680 @default.
• W2016124523 hasConceptScore W2016124523C207001950 @default.
• W2016124523 hasConceptScore W2016124523C2776401185 @default.
• W2016124523 hasConceptScore W2016124523C2776885963 @default.
• W2016124523 hasConceptScore W2016124523C2777389121 @default.
• W2016124523 hasConceptScore W2016124523C2777803847 @default.
• W2016124523 hasConceptScore W2016124523C2781063702 @default.
• W2016124523 hasConceptScore W2016124523C42533223 @default.
• W2016124523 hasConceptScore W2016124523C55493867 @default.
• W2016124523 hasConceptScore W2016124523C71924100 @default.
• W2016124523 hasConceptScore W2016124523C86803240 @default.
• W2016124523 hasConceptScore W2016124523C98274493 @default.
• W2016124523 hasIssue "1" @default.
• W2016124523 hasLocation W20161245231 @default.
• W2016124523 hasLocation W20161245232 @default.
• W2016124523 hasOpenAccess W2016124523 @default.
• W2016124523 hasPrimaryLocation W20161245231 @default.
• W2016124523 hasRelatedWork W127097545 @default.
• W2016124523 hasRelatedWork W1966153991 @default.
• W2016124523 hasRelatedWork W1968272849 @default.
• W2016124523 hasRelatedWork W1968920775 @default.
• W2016124523 hasRelatedWork W1974049279 @default.
• W2016124523 hasRelatedWork W2013581064 @default.
• W2016124523 hasRelatedWork W2016124523 @default.
• W2016124523 hasRelatedWork W2017543502 @default.
• W2016124523 hasRelatedWork W4224304066 @default.
• W2016124523 hasRelatedWork W86576500 @default.
• W2016124523 hasVolume "337" @default.
• W2016124523 isParatext "false" @default.

• next