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- W2016124762 abstract "Cerebrospinal fluid (CSF) biomarkers have been extensively studied as diagnostic marker for Alzheimer's disease (AD). However, results are variable probably due to lumbar puncture (LP) procedure, CSF collection and transport. This inter-center variability highlights the need for an efficient standardization of clinical procedures and techniques. The aims of this study were firstly to compare the LP procedure and CSF transport process between in all French Memory Centers and secondly to evaluate the incidence of LP side effects in 100 patients with cognitive disturbances. LP practice and side effect prospective questionnaires were sent to all French Memory Centers in May 2010. All data were collected until the end of July 2010. 18 out of 26 Memory Centers replied with filled questionnaires. Although, these centers did not have the same LP procedure and CSF transport, the majority of them proceeded according to Innogenetics's advices concerning the use of polypropylene tubes, transport duration and sample conditioning. Polypropylene tubes were different from one center to the other. CSF volume, pharmacological premedication and prevention of post-LP syndrome were variable in all responding center. The prospective study carried out in 100 patients revealed a very good LP acceptability (93/100 patients). LP feasibility was 97 % (90/93) and failed LP were consequently performed with success using radiological scopes. We observed 3 minor complications were observed. All French Centers complied with Innogenetics’ recommendations for pretechnical CSF procedures; however each Center put in place its own procedure that was different between centers. It will be very interesting to compare cutt-off and result values for Abeta tau and p181 tau between several centers that used their own procedures. Acceptability and safety were very good in our short but significant prospective study. These results confirm the data of Zetterberg et al 2010." @default.
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- W2016124762 date "2011-07-01" @default.
- W2016124762 modified "2023-09-27" @default.
- W2016124762 title "P1-136: Multicenter study on procedure, feasibility and safety of lumbar puncture in 18 French memory centers" @default.
- W2016124762 doi "https://doi.org/10.1016/j.jalz.2011.05.416" @default.
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